Müller-Fassbender H
Rheumazentrum Bad Abbach, II Medizinische Klinik, Bad Abbach, Federal Republic of Germany.
Am J Med. 1987 Nov 20;83(5A):81-3. doi: 10.1016/0002-9343(87)90857-6.
Thirty-six subjects with osteoarthritis of the knee, the hip, and/or the spine were enrolled in a randomized double-blind study. Patients received a daily oral dose of 1,200 mg of S-adenosylmethionine (SAMe) or 1,200 mg of ibuprofen for four weeks. Morning stiffness, pain at rest, pain on motion, crepitus, swelling, and limitation of motion of the affected joints were assessed before and after treatment. The total score obtained by the evaluation of all the individual clinical parameters improved to the same extent in patients treated with SAMe or ibuprofen. Both treatments were well tolerated and no patient from either group withdrew from the study.
三十六名患有膝关节、髋关节和/或脊柱骨关节炎的受试者参加了一项随机双盲研究。患者连续四周每日口服1200毫克S-腺苷甲硫氨酸（SAMe）或1200毫克布洛芬。在治疗前后评估晨僵、静息痛、运动痛、摩擦音、肿胀以及患关节的活动受限情况。在接受SAMe或布洛芬治疗的患者中，通过评估所有个体临床参数获得的总分改善程度相同。两种治疗的耐受性都很好，两组中均无患者退出研究。
