使用三重四极杆电感耦合等离子体质谱法测定尿液中的226镭。
Determination of 226Ra in Urine Using Triple Quadrupole Inductively Coupled Plasma Mass Spectrometry.
作者信息
Xiao Ge, Liu Yongzhong, Jones Robert L
机构信息
Inorganic and Radiation Analytical Toxicology Branch, Centers for Disease Control and Prevention, 4770 Buford Highway, Mail Stop S110-5, Atlanta, GA 30341, USA.
Battelle Memorial Institute, Integrated Science Solutions, Public Health, Health Business Unit, 2987 Clairmont Rd, Atlanta, GA 30329, USA.
出版信息
Radiat Prot Dosimetry. 2020 Nov 13. doi: 10.1093/rpd/ncaa180.
Measuring 226Ra in urine at low levels is critical for both biomonitoring and radiological emergency response. Here we report a new analytical method to quantify 226Ra, as developed and validated by a simple dilute-and-shoot procedure, followed by Inductively Coupled Plasma-triple quadrupole-mass spectrometry detection using 'No Gas MS-MS' mode. The method provides rapid and accurate results for 226Ra with a limit of detection (LOD) down to 0.007 ng/l (0.26 Bq/l). This LOD is well below the recommended action levels for 226Ra detection in children and pregnant women (C/P) set by the Clinical Decision Guide (NCRP Report #161). Results for 226Ra obtained by this method are within ±7.0% of the target values of standard reference materials spiked in the urine.
低水平测量尿液中的226镭对于生物监测和放射应急响应都至关重要。在此，我们报告一种新的分析方法来定量226镭，该方法通过简单的稀释进样程序开发并验证，随后采用“无气体MS-MS”模式的电感耦合等离子体-三重四极杆-质谱检测。该方法为226镭提供快速准确的结果，检测限（LOD）低至0.007 ng/l（0.26 Bq/l）。此检测限远低于临床决策指南（NCRP报告#161）设定的儿童和孕妇（C/P）226镭检测推荐行动水平。通过该方法获得的226镭结果在尿液中加标的标准参考物质目标值的±7.0%范围内。
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