Xiao Ge, Saunders David, Jones Robert L, Caldwell Kathleen L
Inorganic and Radiation Analytical Toxicology Branch, Centers for Disease Control and Prevention, 4770 Buford HWY, Mail Stop F50, Atlanta, GA 30341, USA.
J Radioanal Nucl Chem. 2016 Jul;301(1):285-291. doi: 10.1007/s10967-014-3103-4. Epub 2016 Mar 21.
Quantification of Am in urine at low levels is important for assessment of individuals' or populations' accidental, environmental, or terrorism-related internal contamination, but no convenient, precise method has been established to rapidly determine these low levels. Here we report a new analytical method to measure Am as developed and validated at the Centers for Disease Control and Prevention (CDC) by means of the selective retention of Am from urine directly on DGA resin, followed by SF-ICP-MS detection. The method provides rapid results with a Limit of Detection (LOD) of 0.22 pg/L (0.028 Bq/L), which is lower than 1/3 of the C/P CDG for Am at 5 days post-exposure. The results obtained by this method closely agree with CDC values as measured by Liquid Scintillation Counting, and with National Institute of Standards Technology (NIST) Certified Reference Materials (CRM) target values.
对尿液中低含量镅进行定量分析，对于评估个人或人群因意外、环境或与恐怖主义相关的内部污染情况很重要，但目前尚未建立便捷、精确的方法来快速测定这些低含量镅。在此，我们报告一种新的分析方法，该方法是美国疾病控制与预防中心（CDC）研发并验证的，通过将尿液中的镅直接选择性保留在二癸基胺（DGA）树脂上，随后采用扇形场电感耦合等离子体质谱（SF-ICP-MS）检测来测定镅。该方法能快速得出结果，检测限（LOD）为0.22皮克/升（0.028贝克勒尔/升），低于暴露后5天镅的摄入待积活度浓度指导值（C/P CDG）的1/3。此方法所得结果与用液体闪烁计数法测得的CDC值以及美国国家标准与技术研究院（NIST）认证参考物质（CRM）的目标值高度吻合。
