Division of Cardiology, Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Division of Cardiology, University of California Riverside School of Medicine, Riverside, CA, USA.
Am J Cardiovasc Drugs. 2021 Jul;21(4):411-417. doi: 10.1007/s40256-020-00451-9. Epub 2020 Nov 13.
Premature cardiovascular disease among the HIV-infected population is of great concern among clinicians. The increased life expectancy of HIV-infected individuals is mainly due to the early detection of infection and the advent of antiretroviral therapy. Once known as a deadly disease, HIV infection has transitioned into a chronic condition. Cardiovascular disease in this population is thought to progress early due to traditional and non-traditional risk factors. Early detection of subclinical atherosclerosis has become a center of focus in research as our complete understanding of this process it not yet well known. Advancements in cardiac computed tomography angiography has enabled the exploration of coronary artery disease by further evaluation of coronary stenosis and plaque analysis. An increase in cardiovascular event rates in this population is currently thought to be linked to antiretroviral therapy, Framingham risk factors, and HIV. We sought to present an updated comprehensive review of the available literature on HIV related to atherosclerosis and cardiovascular risk.
在临床医生中，艾滋病毒感染者的心血管疾病过早发生是一个非常关注的问题。艾滋病毒感染者预期寿命的延长主要是由于感染的早期发现和抗逆转录病毒疗法的出现。曾经被认为是一种致命的疾病，艾滋病毒感染已经转变为一种慢性疾病。由于传统和非传统的危险因素，人们认为该人群的心血管疾病会提前发展。由于我们对这一过程的了解还不完全，因此早期检测亚临床动脉粥样硬化已成为研究的重点。心脏计算机断层血管造影术的进步使我们能够通过进一步评估冠状动脉狭窄和斑块分析来探索冠心病。目前认为，该人群心血管事件发生率的增加与抗逆转录病毒疗法、弗雷明汉风险因素和 HIV 有关。我们旨在对有关动脉粥样硬化和心血管风险的与 HIV 相关的现有文献进行全面的更新综述。
