Sahu Suchanda, Routray Samapika
Department of Biochemistry, All India Institute of Medical Sciences, Bhubaneswar, India.
Department of Dentistry, All India Institute of Medical Sciences, Bhubaneswar, India.
J Oral Pathol Med. 2021 Feb;50(2):123-128. doi: 10.1111/jop.13126. Epub 2021 Feb 2.
The 5-year survival rates in OSCC depend on the stage at diagnosis. Patients have better survival and favourable outcomes if detected early, as compared to those diagnosed in advanced stages. Apart from biopsy and mucosal scraping examinations, exosomes from saliva and blood are emerging as an accessible source for diagnosis and providing additional information about the tumour's characteristics. Hence, the study of tumour-derived exosomal (TEX) biomarkers obtained from a liquid biopsy is emerging as a promising diagnostic tool. In this systematic review, our effort is to assess the role of TEX as a biomarker.
口腔鳞状细胞癌（OSCC）的5年生存率取决于诊断时的分期。与晚期诊断的患者相比，如果早期发现，患者的生存率更高，预后也更好。除了活检和黏膜刮片检查外，唾液和血液中的外泌体正成为一种可获取的诊断来源，并能提供有关肿瘤特征的更多信息。因此，从液体活检中获取的肿瘤源性外泌体（TEX）生物标志物的研究正成为一种有前景的诊断工具。在这项系统评价中，我们致力于评估TEX作为生物标志物的作用。
