Zhao Bo, Li Zuntai, Li Ronghua
Key Laboratory of Advanced Intelligent Protective Equipment Technology (Hebei University of Technology), Ministry of Education, Tianjin, China.
Department of Stomatology, Tianjin First Central Hospital, Tianjin, China.
Front Oncol. 2025 Jan 16;14:1502283. doi: 10.3389/fonc.2024.1502283. eCollection 2024.
Oral squamous cell carcinoma (OSCC) accounts for approximately 90% of all oral cancers, significantly impacting the survival and quality of life of patients. Exosomes, small extracellular vesicles released by cells, play a crucial role in intercellular communication in cancer. Nevertheless, their function and mechanism in OSCC remain elusive. Search Pubmed, Web of Science, and Cochrane Library using keywords OSCC, exome, diagnosis, and treatment to review the research progress of exome in OSCC. Based on these results, this review starting from the biosynthesis, structure, and contents of exosomes, elaborates on the research progress of exosomes in the diagnosis and treatment of OSCC. It explores the potential of exosomes in the diagnosis and treatment of OSCC, and briefly describes the challenges researchers currently face.
口腔鳞状细胞癌（OSCC）约占所有口腔癌的90%，对患者的生存和生活质量有重大影响。外泌体是细胞释放的小细胞外囊泡，在癌症的细胞间通讯中起关键作用。然而，它们在OSCC中的功能和机制仍不清楚。使用关键词OSCC、外显子组、诊断和治疗在PubMed、科学网和考科蓝图书馆进行检索，以综述外显子组在OSCC中的研究进展。基于这些结果，本综述从外泌体的生物合成、结构和内容入手，阐述了外泌体在OSCC诊断和治疗中的研究进展。它探讨了外泌体在OSCC诊断和治疗中的潜力，并简要描述了研究人员目前面临的挑战。
