Guan Guijian, Win Khin Yin, Yao Xiang, Yang Wensheng, Han Ming-Yong
Institute of Molecular Plus, Tianjin University, No.11 Building, 92 Weijin Road, Nankai District, Tianjin, 300072, P.R. China.
Institute of Materials Research and Engineering, A*STAR, 2 Fusionopolis Way, Singapore, 138634, Singapore.
Adv Healthc Mater. 2021 Feb;10(3):e2001158. doi: 10.1002/adhm.202001158. Epub 2020 Nov 13.
With the wide utilization of antibiotics, antibiotic-resistant bacteria have been often developed more frequently to cause potential global catastrophic consequences. Emerging photothermal ablation has been attracting extensive research interest for quick/effective eradication of pathogenic bacteria from contaminated surroundings and infected body. In this field, anisotropic gold nanostructures with tunable size/morphologies have been demonstrated to exhibit their outstanding photothermal performance through strong plasmonic absorption of near-infrared (NIR) light, efficient light to heat conversion, and easy surface modification for targeting bacteria. To this end, this review first introduces thermal treatment of infectious diseases followed by photothermal therapy via heat generation on NIR-absorbing gold nanostructures. Then, the usual synthesis and spectral features of diversified gold nanostructures and composites are systematically overviewed with the emphasis on the importance of size, shape, and composition to achieve strong plasmonic absorption in NIR region. Further, the innovated photothermal applications of gold nanostructures are comprehensively demonstrated to combat against bacterial infections, and some constructive suggestions are also discussed to improve photothermal technologies for practical applications.
随着抗生素的广泛使用，抗生素耐药菌的产生频率往往更高，从而可能导致全球灾难性后果。新兴的光热消融技术因能快速有效地从受污染环境和感染部位清除病原菌而备受广泛研究关注。在该领域，具有可调尺寸/形貌的各向异性金纳米结构已被证明通过对近红外（NIR）光的强等离子体吸收、高效的光热转换以及易于进行靶向细菌的表面修饰，展现出卓越的光热性能。为此，本综述首先介绍传染病的热处理，接着阐述通过近红外吸收金纳米结构产热进行光热治疗。然后，系统地概述了各种金纳米结构和复合材料的常规合成方法及光谱特征，重点强调尺寸、形状和组成对于在近红外区域实现强等离子体吸收的重要性。此外，全面展示了金纳米结构在对抗细菌感染方面的创新光热应用，并讨论了一些建设性建议以改进光热技术用于实际应用。
