环状 RNAs 作为重要的调控因子出现，具有很大的临床应用潜力在胃癌中。

Circular RNAs emerge as important regulators with great potential for clinical application in gastric cancer.

机构信息

Key Laboratory of Medical Science & Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu Province 212013, China.

Department of Clinical Laboratory, The First People's Hospital of Kunshan Affiliated to Jiangsu University, Suzhou, Jiangsu Province 215300, China.

出版信息

Biomark Med. 2021 Jan;15(1):69-82. doi: 10.2217/bmm-2020-0591. Epub 2020 Nov 13.

DOI:10.2217/bmm-2020-0591

PMID:33185463

Abstract

Gastric cancer (GC) is a common digestive malignancy with a high-ranking morbidity and mortality. Therefore, it is urgent to identify novel indicators and develop new strategies for clinical diagnosis and treatment of GC. As a type of noncoding RNA, circular RNAs (circRNAs) have received increased attention in GC during recent years. To more comprehensively understand current research progress on circRNAs in GC, in this review, we introduce basic knowledge of circRNAs, summarize abnormally expressed circRNAs and discuss their functions and regulatory molecular mechanisms in GC. Then, we review potential applications of circRNAs for GC diagnosis, prognosis and treatment. Finally, we conclude by highlighting major advancements of circRNAs in GC research, and we discuss existing challenges and possible future research directions of GC-associated circRNAs.

摘要

胃癌（GC）是一种常见的消化道恶性肿瘤，发病率和死亡率都很高。因此，迫切需要寻找新的标志物并为 GC 的临床诊断和治疗开发新的策略。环状 RNA（circRNA）作为一种非编码 RNA，近年来在 GC 中受到越来越多的关注。为了更全面地了解 circRNAs 在 GC 中的研究进展，在本综述中，我们介绍了 circRNAs 的基本知识，总结了异常表达的 circRNAs，并讨论了它们在 GC 中的功能和调控分子机制。然后，我们综述了 circRNAs 在 GC 诊断、预后和治疗中的潜在应用。最后，我们通过突出 circRNAs 在 GC 研究中的主要进展，讨论了 GC 相关 circRNAs 存在的挑战和可能的未来研究方向。