Department of Gastroenterology, The Second Affiliated Hospital of the University of South China, Hengyang, 421001 Hunan Province, China.
Biomed Res Int. 2020 Jun 30;2020:2790679. doi: 10.1155/2020/2790679. eCollection 2020.
Circular RNAs (circRNAs), as a recently established group of endogenous noncoding RNAs, have been involved in the occurrence and development of different malignancies. Gastric cancer (GC) remains a globally significant contributor to death in cancer patients due to insufficient early diagnosis, limited treatment measures, and poor prognosis. An increasing number of studies have found that many circRNAs are dysregulated in GC and are closely associated with its tumorigenesis and metastasis. Thus, circRNAs have the potential to serve as diagnostic and prognostic biomarkers and even therapeutic targets. This review comprehensively summarizes the most recent findings on how circRNAs influence GC progression and their clinical value. In addition, we present several methological deficiencies in the studies and provide some promising ideas for future research.
环状 RNA（circRNAs）作为最近发现的一组内源性非编码 RNA，参与了多种恶性肿瘤的发生和发展。胃癌（GC）仍然是导致癌症患者死亡的一个重要原因，这是由于早期诊断不足、治疗措施有限和预后不良。越来越多的研究发现，许多 circRNAs 在 GC 中失调，与肿瘤的发生和转移密切相关。因此，circRNAs 有可能成为诊断和预后的生物标志物，甚至是治疗靶点。本综述全面总结了 circRNAs 影响 GC 进展及其临床价值的最新发现。此外，我们还提出了这些研究中存在的几个方法学缺陷，并为未来的研究提供了一些有前景的思路。
