糖尿病神经病变中的生物标志物
Biomarkers in diabetic neuropathy.
作者信息
Adki Kaveri M, Kulkarni Yogesh A
机构信息
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's NMIMS, Mumbai, India.
出版信息
Arch Physiol Biochem. 2023 Apr;129(2):460-475. doi: 10.1080/13813455.2020.1837183. Epub 2020 Nov 13.
CONTEXT
The prevalence of diabetic neuropathy is drastically increasing in the world. To halt the progression of diabetic neuropathy, there is an unmet need to have potential biomarkers for the diagnosis and new drug discovery.
OBJECTIVE
To study various biomarkers involved in the pathogenesis of diabetic neuropathy.
METHODS
The literature was searched with the help of various scientific databases and resources like PubMed, ProQuest, Scopus, and Google scholar from the year 1976 to 2020.
RESULTS
Biomarkers of diabetic neuropathy are categorised as inflammatory biomarkers such as MCP-1, VEGF, TRPV1, NF-κB; oxidative biomarkers such as adiponectin, NFE2L2; enzyme biomarkers like NADPH, ceruloplasmin, HO-1, DPP-4, PARP α; miscellaneous biomarkers such as SIRT1, caveolin 1, MALAT1, and microRNA. All biomarkers have a significant role in the pathogenesis of diabetic neuropathy.
CONCLUSION
These biomarkers have a potential role in the progression of diabetic neuropathy and can be considered as potential targets for new drug discovery.
背景
糖尿病神经病变在全球的患病率正在急剧上升。为了阻止糖尿病神经病变的进展，对于用于诊断和新药研发的潜在生物标志物存在未满足的需求。
目的
研究参与糖尿病神经病变发病机制的各种生物标志物。
方法
借助各种科学数据库和资源（如PubMed、ProQuest、Scopus和谷歌学术），检索了1976年至2020年的文献。
结果
糖尿病神经病变的生物标志物分为炎症生物标志物，如单核细胞趋化蛋白-1、血管内皮生长因子、瞬时受体电位香草酸亚型1、核因子κB；氧化生物标志物，如脂联素、核因子E2相关因子2；酶生物标志物，如还原型辅酶Ⅱ、铜蓝蛋白、血红素加氧酶-1、二肽基肽酶-4、聚（ADP-核糖）聚合酶α；其他生物标志物，如沉默信息调节因子1、小窝蛋白1、转移相关肺腺癌转录本1和微小RNA。所有生物标志物在糖尿病神经病变的发病机制中都起着重要作用。
结论
这些生物标志物在糖尿病神经病变的进展中具有潜在作用，可被视为新药研发的潜在靶点。
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