Department of Adult Health Nursing, School of Nursing, Aksum University, Aksum, Ethiopia.
Department of Emergency Nursing, School of Nursing, Aksum University, Aksum, Ethiopia.
J Diabetes Res. 2021 Feb 4;2021:5304124. doi: 10.1155/2021/5304124. eCollection 2021.
Currently, diabetic peripheral neuropathy (DPN) is one of the most severe complications of diabetes mellitus (DM). Despite the seriousness of this problem, limited evidence is available on the prevalence of diabetic peripheral neuropathy among patients with diabetes mellitus in Ethiopia. In Ethiopia, there were no updated studies that estimate the national prevalence of DPN. Hence, this systematic review and meta-analysis provided a national prevalence of diabetic peripheral neuropathy among patients with diabetes mellitus in Ethiopia.
This study was submitted for registration with the International Prospective Register of Systematic Reviews (PROSPERO) in March 2020 and accepted with the registration number CRD42020173831. Different database searching engines were searched online to retrieve related articles, including PubMed, Scopus, Google Scholar, African Journals Online, World Health Organization (WHO) Afro Library, and Cochrane Review. The reviewers used the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guideline in the reviewing process. In this systematic review and meta-analysis, all published and unpublished articles were analyzed. The reviewers used the random effects model to estimate the pooled prevalence of diabetic peripheral neuropathy among diabetes mellitus patients. The reviewers conducted the statistical analysis using the R version 3.5.3 and RStudio version 1.2.5033 software for Windows. The reviewers evaluated the heterogeneity across the included studies by the inconsistency index ( ). The reviewers examined the publication bias by the funnel plot.
The search of the databases produced 245 papers. After checking the inclusion and exclusion criteria, 38 articles with 14029 total patients with diabetes mellitus were found suitable for the review. Except for three (retrospective cohort study), all studies were cross-sectional. The overall pooled prevalence of diabetic peripheral neuropathy was 22% (95% CI 18% to 26%). The subgroup analysis of diabetic peripheral neuropathy among patients with diabetes in the different regions was 23% (95% CI 17% to 29%) in Addis Ababa, 27% (95% CI 16% to 38%) in Oromia, 16% (95% CI 14% to 18%) in South nation and nationalities, and 15% (95% CI 6% to 24%) in Amhara.
More than one-fifth of patients with diabetes have diabetic peripheral neuropathy. According to this study, the prevalence of diabetic peripheral neuropathy in Ethiopia is considerably high. This evidence suggests that attention should be given to patients with diabetes in monitoring patients' blood glucose.
目前，糖尿病周围神经病变（DPN）是糖尿病（DM）最严重的并发症之一。尽管这个问题很严重，但在埃塞俄比亚，关于糖尿病患者中糖尿病周围神经病变的患病率的证据有限。在埃塞俄比亚，没有更新的研究来估计 DPN 的全国患病率。因此，这项系统评价和荟萃分析提供了埃塞俄比亚糖尿病患者中糖尿病周围神经病变的全国患病率。
本研究于 2020 年 3 月向国际前瞻性系统评价注册库（PROSPERO）提交了注册，并获得了注册号 CRD42020173831。研究人员通过在线搜索不同的数据库检索引擎，包括 PubMed、Scopus、Google Scholar、African Journals Online、世界卫生组织（WHO）非洲图书馆和 Cochrane Review，检索相关文章。在审查过程中，审查员使用了系统评价和荟萃分析的首选报告项目（PRISMA）指南。在这项系统评价和荟萃分析中，分析了所有已发表和未发表的文章。审查员使用随机效应模型来估计糖尿病患者中糖尿病周围神经病变的总体患病率。审查员使用 R 版本 3.5.3 和 RStudio 版本 1.2.5033 软件在 Windows 上进行统计分析。审查员通过不一致指数（ ）评估纳入研究之间的异质性。审查员通过漏斗图评估发表偏倚。
数据库搜索产生了 245 篇论文。在检查了纳入和排除标准后，发现 38 篇文章共纳入了 14029 名糖尿病患者，适合进行综述。除了三项（回顾性队列研究），所有研究都是横断面研究。糖尿病周围神经病变的总体合并患病率为 22%（95%CI 18%至 26%）。在亚组分析中，在不同地区的糖尿病患者中，亚组分析发现，在亚的斯亚贝巴的患病率为 23%（95%CI 17%至 29%），在奥罗米亚的患病率为 27%（95%CI 16%至 38%），在南民族和国民的患病率为 16%（95%CI 14%至 18%），在阿姆哈拉的患病率为 15%（95%CI 6%至 24%）。
超过五分之一的糖尿病患者患有糖尿病周围神经病变。根据这项研究，埃塞俄比亚的糖尿病周围神经病变患病率相当高。这一证据表明，应关注监测患者血糖的糖尿病患者。
