Department of Cardiology, University of Health Sciences Samsun Training and Research Hospital, Samsun.
Department of Cardiology, University of Ordu Training and Research Hospital, Ordu.
J Cardiovasc Med (Hagerstown). 2021 Mar 1;22(3):197-203. doi: 10.2459/JCM.0000000000001135.
The aim of the current study was to evaluate P-wave dispersion (PWD) as a predictor of atrial fibrillation in patients with newly diagnosed COVID-19. In addition, the relationship between the PWD and inflammation parameters was investigated.
A total of 140 newly diagnosed COVID-19 patients and 140 age- and sex-matched healthy individuals were included in the study. The risk of atrial fibrillation was evaluated by calculating the electrocardiographic PWD. C-reactive protein (CRP), white blood cell, neutrophil and neutrophil-to-lymphocyte ratio (NLR) were measured in patients with newly diagnosed COVID-19.
PWD, white blood cell, NLR and CRP levels were significantly higher in the COVID-19 group than the control group. There was a significant positive correlation between PWD and CRP level (rs = 0.510, P < 0.001) and NLR in COVID-19 group (rs = 0.302, P = 0.001). In their follow-up, 13 (9.3%) patients, 11 of whom were in the ICU, developed new atrial fibrillation.
Our study showed for the first time in literature that the PWD, evaluated electrocardiographically in patients with newly diagnosed COVID-19, was prolonged compared with normal healthy individuals. A positive correlation was found between PWD, CRP level and NLR. We believe that pretreatment evaluation of PWD in patients with newly diagnosed COVID-19 would be beneficial for predicting atrial fibrillation risk.
本研究旨在评估 P 波离散度（PWD）作为新发 COVID-19 患者心房颤动的预测指标。此外，还研究了 PWD 与炎症参数之间的关系。
共纳入 140 例新发 COVID-19 患者和 140 名年龄和性别匹配的健康对照者。通过计算心电图 PWD 评估心房颤动的风险。测量新发 COVID-19 患者的 C 反应蛋白（CRP）、白细胞、中性粒细胞和中性粒细胞与淋巴细胞比值（NLR）。
COVID-19 组的 PWD、白细胞、NLR 和 CRP 水平明显高于对照组。COVID-19 组的 PWD 与 CRP 水平呈显著正相关（rs=0.510，P<0.001），与 NLR 呈显著正相关（rs=0.302，P=0.001）。在随访中，有 13 例（9.3%）患者，其中 11 例在 ICU，新发心房颤动。
本研究首次在文献中表明，新发 COVID-19 患者心电图评估的 PWD 较正常健康个体延长。PWD 与 CRP 水平和 NLR 之间存在正相关。我们认为，对新发 COVID-19 患者进行 PWD 的预处理评估将有助于预测心房颤动的风险。
