Faculty of Medicine, Titu Maiorescu University, Bucharest, Romania.
Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Int J Immunopathol Pharmacol. 2023 Jan-Dec;37:3946320231178769. doi: 10.1177/03946320231178769.
At the level of the genital system, ovarian neoplasm is the most frequent cause of morbidity and mortality. In the specialized literature, the coexistence of an inflammatory process is admitted from the early stages of the evolution of this pathology. Starting from the importance of this process, both in determinism and in the evolution of carcinogenesis and summarizing the field of knowledge, for this study we considered two objectives: the first was the presentation of the pathogenic mechanism, through which chronic +ovarian inflammation is involved in the process of carcinogenesis, and the second is the justification of the clinical utility of the three parameters, accepted as biomarkers of systemic inflammation: neutrophil-lymphocyte ratio, platelet lymphocyte ratio, and lymphocyte-monocyte ratio in the assessment of prognosis. The study highlights the acceptance of these hematological parameters, with practical utility, as prognostic biomarkers in ovarian cancer, based on the intrinsic link with cancer-associated inflammatory mediators. Based on the data from the specialized literature, the conclusion is that in ovarian cancer, the inflammatory process induced by the presence of the tumor, induces changes in the types of circulating leukocytes, with immediate effects on the markers of systemic inflammation.
在生殖系统水平上，卵巢肿瘤是发病率和死亡率最常见的原因。在专业文献中，从这种病理学演变的早期就承认存在炎症过程。鉴于该过程的重要性，无论是在决定因素还是在癌变的演变中，都总结了这一领域的知识，因此，我们为这项研究考虑了两个目标：第一个目标是介绍发病机制，即慢性+卵巢炎症如何参与癌变过程；第二个目标是证明三个被接受为系统性炎症生物标志物的参数（中性粒细胞-淋巴细胞比、血小板-淋巴细胞比和淋巴细胞-单核细胞比）在评估预后中的临床实用性。该研究强调了这些具有实用价值的血液学参数作为卵巢癌预后生物标志物的接受程度，这是基于其与癌症相关炎症介质的内在联系。基于专业文献中的数据，结论是在卵巢癌中，肿瘤存在引起的炎症过程会引起循环白细胞类型的变化，对系统性炎症标志物产生直接影响。
