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Epidemiology, Pathophysiology, and Treatment Strategies of Concussions: A Comprehensive Review.

作者信息

Ahmed Zubair, Chaudhary Fihr, Fraix Marcel P, Agrawal Devendra K

机构信息

Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona CA 91766.

出版信息

Fortune J Health Sci. 2024;7(2):197-215. doi: 10.26502/fjhs.178. Epub 2024 Apr 12.


DOI:10.26502/fjhs.178
PMID:38708028
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11067689/
Abstract

A concussion is a particular manifestation of a traumatic brain injury, which is the leading cause of mortality and disabilities across the globe. The global prevalence of traumatic brain injury is estimated to be 939 instances per 100,000 individuals, with approximately 5.48 million people per year experiencing severe traumatic brain injury. Epidemiology varies amongst different countries by socioeconomic status with diverse clinical manifestations. Additionally, classifying concussions is an ambiguous process as clinical diagnoses are the only current classification method, and morbidity rates differ by demographic location as well as populations examined. In this article, we critically reviewed the pathophysiology of concussions, classification methods, treatment options available including both pharmacologic and nonpharmacologic intervention methods, etiologies as well as global etiologic differences associated with them, and clinical manifestations along with their associated morbidities. Furthermore, analysis of the current research regarding the incidence of concussion based traumatic brain injuries and future directions are discussed. Investigation on the efficacy of new therapeutic-related interventions such as exosome therapy and electromagnetic field stimulation are warranted to properly manage and treat concussion-induced traumatic brain injury.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f03/11067689/c9ba2b468791/nihms-1986527-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f03/11067689/c99eed87772b/nihms-1986527-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f03/11067689/d22123c4581c/nihms-1986527-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f03/11067689/c29b91def634/nihms-1986527-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f03/11067689/8195884d7a1d/nihms-1986527-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f03/11067689/c9ba2b468791/nihms-1986527-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f03/11067689/c99eed87772b/nihms-1986527-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f03/11067689/d22123c4581c/nihms-1986527-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f03/11067689/c29b91def634/nihms-1986527-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f03/11067689/8195884d7a1d/nihms-1986527-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f03/11067689/c9ba2b468791/nihms-1986527-f0005.jpg

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Epidemiology, Pathophysiology, and Treatment Strategies of Concussions: A Comprehensive Review.

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[5]
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[6]
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本文引用的文献

[1]
Transcriptional and Translational Regulation of Differentially Expressed Genes in Yucatan Miniswine Brain Tissues following Traumatic Brain Injury.

J Bioinform Syst Biol. 2024

[2]
Transcriptomic Analysis of Gene Expression and Effect of Electromagnetic Field in Brain Tissue after Traumatic Brain Injury.

J Biotechnol Biomed. 2024

[3]
Modulation of Inflammatory Response by Electromagnetic Field Stimulation in Traumatic Brain Injury in Yucatan Swine.

J Surg Res (Houst). 2024

[4]
Mitochondrial Calcium Overload Plays a Causal Role in Oxidative Stress in the Failing Heart.

Biomolecules. 2023-9-19

[5]
A Swine Model of Neural Circuit Electromagnetic Fields: Effects of Immediate Electromagnetic Field Stimulation on Cortical Injury.

Cureus. 2023-8-19

[6]
A Swine Model of Traumatic Brain Injury: Effects of Neuronally Generated Electromagnetic Fields and Electromagnetic Field Stimulation on Traumatic Brain Injury-Related Changes.

Cureus. 2023-7-27

[7]
A Swine Model of Changes in the Neuronal Electromagnetic Field After Traumatic Brain Injury: A Pilot Study.

Cureus. 2023-7-12

[8]
Cellular Mechanisms of Electromagnetic Field in Traumatic Brain Injury.

J Biotechnol Biomed. 2023

[9]
Acute evaluation of sport-related concussion and implications for the Sport Concussion Assessment Tool (SCAT6) for adults, adolescents and children: a systematic review.

Br J Sports Med. 2023-6

[10]
An Evaluation of the Emerging Techniques in Sports-Related Concussion.

J Clin Neurophysiol. 2023-7-1

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