Biology Department, University of North Carolina, Chapel Hill, NC, 27599, USA.
Biology Department, University of North Carolina, Chapel Hill, NC, 27599, USA; Marine Biological Laboratory, Woods Hole, MA, 02543, USA.
Curr Opin Cell Biol. 2021 Feb;68:105-112. doi: 10.1016/j.ceb.2020.10.007. Epub 2020 Nov 11.
Septins are conserved guanine nucleotide-binding proteins that polymerize into filaments at the cell cortex or in association with other cytoskeletal proteins, such as actin or microtubules. As integral players in many morphogenic and signaling events, septins form scaffolds important for the recruitment of the cytokinetic machinery, organization of the plasma membrane, and orientation of cell polarity. Mutations in septins or their misregulation are associated with numerous diseases. Despite growing appreciation for the importance of septins in different aspects of cell biology and disease, septins remain relatively poorly understood compared with other cytoskeletal proteins. Here in this review, we highlight some of the recent developments of the last two years in the field of septin cell biology.
septins 是保守的鸟嘌呤核苷酸结合蛋白，它们在细胞皮层或与其他细胞骨架蛋白（如肌动蛋白或微管）结合时聚集成纤维。作为许多形态发生和信号事件中的重要组成部分， septins 形成支架，对于细胞分裂机制的募集、质膜的组织和细胞极性的定向非常重要。 septin 突变或其调控异常与许多疾病有关。尽管人们越来越认识到 septins 在细胞生物学和疾病的不同方面的重要性，但与其他细胞骨架蛋白相比， septins 的了解仍然相对较少。在这篇综述中，我们重点介绍了过去两年中 septin 细胞生物学领域的一些最新进展。
