胞壁酰二肽对从局部细菌感染中分离出的中性粒细胞的刺激作用。
Stimulatory effects of muramyl dipeptide upon neutrophils isolated from a local bacterial infection.
作者信息
Lamont P M, Maier K G, Melton L, Polk H C
机构信息
Department of Surgery, University of Louisville School of Medicine, Kentucky 40292.
出版信息
Br J Exp Pathol. 1987 Oct;68(5):655-61.
This study examined the effects of muramyl dipeptide (MDP) in vivo upon the local inflammatory response to a bacterial challenge. In addition to quantitative bacteriology of the tissues surrounding an infected suture, polymorphonuclear leucocytes (PMN) involved in the local inflammatory response were extracted and estimations made of their number, viability and phagocytic activity. Fewer bacteria were recovered from the muscle around the suture in MDP-treated animals compared to placebo-treated controls (P less than 0.02), although there was no difference in the number of bacteria on the suture itself. Polymorphonuclear leucocytes were present in greater numbers (P less than 0.01), more PMNs were viable (P less than 0.01) and more PMNs had visibly phagocytosed bacteria (P less than 0.01) in the MDP group compared to the placebo group. These data indicate that MDP enhances the local inflammatory response to infection with increased influx, viability and phagocytic activity of PMNs, resulting in improved local control of a test bacterial challenge.
本研究检测了体内胞壁酰二肽（MDP）对细菌攻击引发的局部炎症反应的影响。除了对感染缝线周围组织进行定量细菌学检测外，还提取了参与局部炎症反应的多形核白细胞（PMN），并对其数量、活力和吞噬活性进行了评估。与安慰剂处理的对照组相比，MDP处理的动物缝线周围肌肉中回收的细菌较少（P<0.02），尽管缝线上的细菌数量没有差异。与安慰剂组相比，MDP组中多形核白细胞数量更多（P<0.01），更多的PMN具有活力（P<0.01），并且更多的PMN明显吞噬了细菌（P<0.01）。这些数据表明，MDP通过增加PMN的流入、活力和吞噬活性来增强对感染的局部炎症反应，从而改善对试验性细菌攻击的局部控制。
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