胞壁酰肽对巨噬细胞迁移的抑制作用。
Inhibition of macrophage migration by muramyl peptides.
作者信息
Nagao S, Tanaka A, Yamamoto Y, Koga T, Onoue K, Shiba T, Kusumoto K, Kotani S
出版信息
Infect Immun. 1979 May;24(2):308-12. doi: 10.1128/iai.24.2.308-312.1979.
Abstract
In the capillary tube migration system a synthetic muramyl dipeptide (MDP; N-acetylmuramyl-L-alanyl-D-isoglutamine), a part of bacterial cell wall peptidoglycans, inhibited the migration of peritoneal exudate macrophages from normal guinea pigs or rats. The migration inhibition was also caused by some MDP-containing peptidoglycan fragments from cell walls of Lactobacillus plantarum and Staphylococcus epidermidis. The migration inhibition could not be explained on the basis of macrophage migration inhibitory factor. A stereochemically highly specific structure of MDP required for its adjuvant activity was also required for the macrophage migration inhibition. These findings suggest that MDP and MDP-containing cell wall fragments may activate macrophages and that this activation may be important in the exertion of their adjuvant activity.
摘要
在毛细管迁移系统中，一种合成的胞壁酰二肽（MDP；N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺），作为细菌细胞壁肽聚糖的一部分，抑制了正常豚鼠或大鼠腹腔渗出巨噬细胞的迁移。来自植物乳杆菌和表皮葡萄球菌细胞壁的一些含MDP的肽聚糖片段也会导致迁移抑制。这种迁移抑制不能用巨噬细胞迁移抑制因子来解释。MDP的佐剂活性所需的立体化学高度特异性结构也是巨噬细胞迁移抑制所必需的。这些发现表明，MDP和含MDP的细胞壁片段可能激活巨噬细胞，并且这种激活可能在其佐剂活性的发挥中起重要作用。
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