Scheyerer Max Joseph, Rohde Axel, Stuermer Konrad Johannes, Kluenter Heinz-Dieter, Bredow Jan, Oikonomidis Stavros, Klußmann Jens Peter, Eysel Peer, Eysel-Gosepath Kathrin
Department of Orthopedic and Trauma Surgery, Medical Faculty, University of Cologne, Cologne, Germany.
Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Cologne, Germany.
Asian Spine J. 2021 Oct;15(5):701-707. doi: 10.31616/asj.2020.0308. Epub 2020 Nov 16.
The physiopathogenesis of adolescent idiopathic scoliosis remains unknown. However, a multifactorial pathogenesis is being assumed. Besides biomechanical, biochemical, and genetic factors, some studies have focused on congenital or acquired abnormalities in the vestibular organ with consecutive development of scoliosis. This study aims to analyze a possible correlation between any vestibular organ congenital or acquired pathologies and scoliosis based on the current literature. Therefore, we conducted a literature search in three databases, with search terms such as "scoliosis," "organ of balance," "idiopathic scoliosis," "vestibular organ," "spine," and "balance." Fifteen studies were selected and used for research. The relationship between scoliosis and vestibular organ abnormalities was recorded from all included works. Seven studies demonstrated a direct correlation between vestibular organ anatomical abnormalities and the form of the scoliotic spine. Another study confirmed the influence of the pathology of the vestibular organ on scoliosis but questioned whether it had an impact on the formation or the progression of the curvature. Others demonstrated a temporal overlap of the embryonic development of the vestibular organ and the beginning of pre-scoliotic characteristics, but their relationship remained questionable. In three studies, the correlation remained unclear, and any context has been denied. It seems unlikely that an isolated vestibular disorder can trigger structural scoliosis. However, the vestibular system pathologies may certainly occur in the multifactorial genesis of idiopathic scoliosis. Whether the correlation refers to the expression or the progression of scoliosis or may even have an influence on both remains unclear. New treatment options could be derived from these findings with a positive influence on the course of the deformity.
青少年特发性脊柱侧弯的病理生理机制尚不清楚。然而，目前认为其发病机制是多因素的。除了生物力学、生化和遗传因素外，一些研究聚焦于前庭器官的先天性或后天性异常以及随后发生的脊柱侧弯。本研究旨在基于现有文献分析前庭器官的任何先天性或后天性病变与脊柱侧弯之间可能存在的相关性。因此，我们在三个数据库中进行了文献检索，检索词包括“脊柱侧弯”“平衡器官”“特发性脊柱侧弯”“前庭器官”“脊柱”和“平衡”。共筛选出15项研究用于此项研究。从所有纳入的研究中记录脊柱侧弯与前庭器官异常之间的关系。7项研究表明前庭器官解剖结构异常与脊柱侧弯的形态之间存在直接关联。另一项研究证实了前庭器官病变对脊柱侧弯有影响，但对其是否影响侧弯的形成或进展提出了质疑。其他研究表明前庭器官的胚胎发育与脊柱侧弯前期特征的起始存在时间上的重叠，但其关系仍存在疑问。在3项研究中，相关性仍不明确，且未发现任何关联背景。孤立的前庭功能障碍似乎不太可能引发结构性脊柱侧弯。然而，前庭系统病变在特发性脊柱侧弯的多因素发病过程中肯定会出现。这种相关性是指脊柱侧弯的表现还是进展，甚至是否对两者都有影响，目前尚不清楚。这些研究结果可能会带来新的治疗选择，对畸形的发展进程产生积极影响。
