Hunan Provincial Engineering Research Center for Food Processing of Aquatic Biotic Resources, School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, Hunan Province 410114, People's Republic of China.
Hunan Provincial Engineering Research Center for Food Processing of Aquatic Biotic Resources, School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, Hunan Province 410114, People's Republic of China.
Int J Biol Macromol. 2021 Jan 15;167:1241-1247. doi: 10.1016/j.ijbiomac.2020.11.078. Epub 2020 Nov 13.
The green hard capsules were prepared with corn nano-starch (CNS) and cellulose nanocrystal (CNC) in this study, the glycerol and carrageenan were used as plasticizer and gelling agent in the CNS/CNC gel solution, respectively. The capsule-films with different CNC content were prepared by casting method, and the dipping method was used in preparation of the corresponding capsules. The compatibility of CNS/CNC capsules was analyzed by Fourier Transform Infrared spectroscopy (FTIR) and X-Ray Diffraction (XRD), and the morphology of the capsules was analyzed by Scanning Electron Microscopy (SEM). The results showed that the tensile strength of the CNS based capsule-film was significantly improved with the addition of CNC. When the content of CNC was 6.0%, the tensile strength increased by 238.10%. The transparency of the capsule with different CNC contents was slightly reduced, but was greater than 87.0%. The loss on drying of CNS/CNC capsule was between 12.87% and 15.03%, and it could be completely dissolved in the artificial gastric juice within 6.0 min, which was in accordance with the provisions of Chinese Pharmacopoeia (2015).
本研究采用玉米纳米淀粉（CNS）和纤维素纳米晶体（CNC）制备绿色硬胶囊，甘油和卡拉胶分别作为 CNS/CNC 凝胶溶液中的增塑剂和胶凝剂。通过浇铸法制备了不同 CNC 含量的胶囊膜，并采用浸渍法制备了相应的胶囊。通过傅里叶变换红外光谱（FTIR）和 X 射线衍射（XRD）分析了 CNS/CNC 胶囊的相容性，通过扫描电子显微镜（SEM）分析了胶囊的形态。结果表明，添加 CNC 可显著提高 CNS 基胶囊膜的拉伸强度。当 CNC 的含量为 6.0%时，拉伸强度增加了 238.10%。不同 CNC 含量的胶囊的透明度略有降低，但仍大于 87.0%。CNS/CNC 胶囊的干燥失重在 12.87%至 15.03%之间，可在 6.0 分钟内完全溶解于人工胃液中，符合 2015 年版《中国药典》的规定。
