The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, Russia.
The Yekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Yekaterinburg, Russia; Institute of Industrial Ecology, The Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russia.
Toxicology. 2021 Jan 15;447:152629. doi: 10.1016/j.tox.2020.152629. Epub 2020 Nov 12.
The authors propose to consider as hormesis phenomenon not only a realization of the Arndt-Schulze rule but any non-monotonic dose-response relationship for a certain outcome that is characterized by changing direction of a response between adjacent ranges of doses of an initiator of this response, the number of such ranges being two or more. This approach is illustrated with results of several in vitro experiments on different established cell lines exposed to CdS or PbS nanoparticles.
作者提出，不仅要将 Arndt-Schulze 规律的实现视为一种激素现象，还要将任何具有特定结果的非单调剂量反应关系视为一种激素现象，这种反应关系的特征是在该反应的启动剂的相邻剂量范围内，反应方向发生变化，这样的范围数量为两个或更多。这种方法通过对不同已建立的细胞系暴露于 CdS 或 PbS 纳米粒子的几项体外实验结果来说明。
