Asimakopoulos Panagiotis, Shaha Ashok R, Nixon Iain J, Shah Jatin P, Randolph Gregory W, Angelos Peter, Zafereo Mark E, Kowalski Luiz P, Hartl Dana M, Olsen Kerry D, Rodrigo Juan P, Vander Poorten Vincent, Mäkitie Antti A, Sanabria Alvaro, Suárez Carlos, Quer Miquel, Civantos Francisco J, Robbins K Thomas, Guntinas-Lichius Orlando, Hamoir Marc, Rinaldo Alessandra, Ferlito Alfio
Head and Neck Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Department of Otorhinolaryngology Head and Neck Surgery, Edinburgh Royal Infirmary, Edinburgh, UK.
Curr Oncol Rep. 2020 Nov 14;23(1):1. doi: 10.1007/s11912-020-00997-6.
In this narrative review, we discuss the indications for elective and therapeutic neck dissections and the postoperative surveillance and treatment options for recurrent nodal disease in patients with well-differentiated thyroid cancer.
Increased availability of advanced imaging modalities has led to an increased detection rate of previously occult nodal disease in thyroid cancer. Nodal metastases are more common in young patients, large primary tumors, specific genotypes, and certain histological types. While clinically evident nodal disease in the lateral neck compartments has a significant oncological impact, particularly in the older age group, microscopic metastases to the central or the lateral neck in well-differentiated thyroid cancer do not significantly affect outcome. As patients with clinically evident nodal disease are associated with worse outcomes, they should be treated surgically in order to reduce rates of regional recurrence and improve survival. The benefit of elective neck dissection remains unverified as the impact of microscopic disease on outcomes is not significant.
在本叙述性综述中,我们讨论了分化型甲状腺癌患者选择性和治疗性颈部清扫术的适应证,以及复发性淋巴结疾病的术后监测和治疗选择。
先进成像模式的可及性增加,导致甲状腺癌中既往隐匿性淋巴结疾病的检出率提高。淋巴结转移在年轻患者、大的原发性肿瘤、特定基因型和某些组织学类型中更为常见。虽然侧颈部区域临床上明显的淋巴结疾病具有显著的肿瘤学影响,特别是在老年人群中,但分化型甲状腺癌中央或侧颈部的微小转移对预后并无显著影响。由于临床上明显的淋巴结疾病患者预后较差,应进行手术治疗以降低区域复发率并提高生存率。由于微小疾病对预后的影响不显著,选择性颈部清扫术的益处仍未得到证实。