Department of dermatology, Peking University People's Hospital, Peking University, Beijing, China.
Dermatol Ther. 2021 Jan;34(1):e14545. doi: 10.1111/dth.14545. Epub 2020 Nov 26.
Camouflage improves the quality of life in vitiligo patients. However, whether the use of camouflage interferes the efficacy of the treatment of vitiligo remains controversial. To evaluate the impact and safety of dihydroxyacetone (DHA)-containing camouflage on the treatment of vitiligo. Thirty patients were enrolled. Comparable vitiliginous patches in each patient were randomly divided into camouflage group or blank group. The therapeutic modalities including topical corticosteroids with or without NB-UVB phototherapy were applied to both groups of lesions. The outcomes were assessed at baseline and then every 4 weeks for up to 12 weeks, including types of repigmentation patterns, percentage of repigmentation, trans epidermal water loss (TEWL), and adverse events. Twenty-eight patients completed the study. There were no differences in repigmentation types and percentage of repigmentation at the endpoint of study between two groups. No difference in TEWL was found at the end of the study between the two groups. Temporary skin irritation (itching and tingling) occurred in one patient in camouflage group after phototherapy between 8 and 12 weeks' treatment. DHA-containing camouflage is a safe make-up for vitiligo. It has little impact on the efficacy of the treatment of vitiligo or on the function of skin barrier.
伪装改善了白癜风患者的生活质量。然而，使用伪装是否会干扰白癜风的治疗效果仍存在争议。为了评估含二羟丙酮（DHA）的伪装对白癜风治疗的影响和安全性。共招募了 30 名患者。每位患者的相似白癜风斑块被随机分为伪装组或空白组。两组病变均应用局部皮质类固醇加或不加 NB-UVB 光疗。在基线和治疗后每 4 周评估一次，共 12 周，包括复色类型、复色百分比、经表皮水分流失（TEWL）和不良事件。28 名患者完成了研究。两组在研究结束时的复色类型和复色百分比无差异。两组在研究结束时 TEWL 无差异。在 8 至 12 周治疗期间，一名伪装组患者在光疗后出现短暂皮肤刺激（瘙痒和刺痛）。含 DHA 的伪装是一种安全的白癜风化妆品。它对白癜风的治疗效果或皮肤屏障功能几乎没有影响。
