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Overview of current status and future direction of clinical trials with 5-fluorouracil in combination with folinic acid.

作者信息

Grem J L, Hoth D F, Hamilton J M, King S A, Leyland-Jones B

机构信息

Investigational Drug Branch, National Cancer Institute, Bethesda, MD 20892.

出版信息

Cancer Treat Rep. 1987 Dec;71(12):1249-64.

PMID:3319136
Abstract
摘要

相似文献

1
Overview of current status and future direction of clinical trials with 5-fluorouracil in combination with folinic acid.5-氟尿嘧啶联合亚叶酸钙临床试验的现状与未来方向概述
Cancer Treat Rep. 1987 Dec;71(12):1249-64.
2
[Treatment of advanced colonic and rectal adenocarcinoma: combination of 5-FU and high-dose folinic acid].
Bull Cancer. 1983;70(5):434-6.
3
Clinical studies of biochemical modulation of 5-fluorouracil by leucovorin in patients with advanced colorectal cancer by the North Central Cancer Treatment Group and Mayo Clinic.由北中部癌症治疗组和梅奥诊所开展的关于亚叶酸对晚期结直肠癌患者5-氟尿嘧啶进行生化调节的临床研究。
NCI Monogr. 1987(5):185-8.
4
[Possible effect of administration methods on pharmacological action. Study of cytostatic therapy in advanced cancer].给药方式对药理作用的可能影响。晚期癌症细胞抑制疗法的研究
Lakartidningen. 1995 Dec 13;92(50):4793-6.
5
Sequential 5-fluorouracil, methotrexate, and calcium leucovorin in metastatic colorectal cancer.转移性结直肠癌中5-氟尿嘧啶、甲氨蝶呤和亚叶酸钙的序贯治疗
Wis Med J. 1988 May;87(5):20-3.
6
[Current status of chemotherapy for colonic, rectal and anal carcinoma].
Schweiz Rundsch Med Prax. 1990 Jul 17;79(29-30):896-8.
7
Systemic therapy of colorectal cancer.结直肠癌的全身治疗
Wis Med J. 1988 May;87(5):27-9.
8
[Up-date of the chemotherapy of carcinoma of the colo-rectum: our experience with 5-fluorouracil and folinic acid in high doses].[结直肠癌化疗的最新进展：我们使用大剂量5-氟尿嘧啶和亚叶酸的经验]
Clin Ter. 1984 Aug 31;110(4):327-39.
9
Severe and fatal toxic effects observed in treatment with high- and low-dose leucovorin plus 5-fluorouracil for colorectal carcinoma.在高剂量和低剂量亚叶酸钙联合5-氟尿嘧啶治疗结直肠癌时观察到严重和致命的毒性作用。
Cancer Treat Rep. 1987 Nov;71(11):1122.
10
Is oxaliplatin combined with weekly bolus 5-fluorouracil and leucovorin an option for stage II and III colon cancer?奥沙利铂联合每周一次大剂量5-氟尿嘧啶和亚叶酸钙对II期和III期结肠癌患者来说是一种可行的治疗方案吗？
Nat Clin Pract Oncol. 2008 Feb;5(2):72-3. doi: 10.1038/ncponc1006.

引用本文的文献

1
Phase II study of weekly vinorelbine and 24-h infusion of high-dose 5-fluorouracil plus leucovorin as first-line treatment of advanced breast cancer.长春瑞滨每周给药联合大剂量5-氟尿嘧啶持续24小时输注及亚叶酸钙作为晚期乳腺癌一线治疗的II期研究
Br J Cancer. 2005 Mar 28;92(6):1013-8. doi: 10.1038/sj.bjc.6602469.
2
A phase II study of high-dose 24 hour continuous infusion 5-FU and leucovorin and low-dose PALA for patients with advanced pancreatic adenocarcinoma: a Southwest Oncology Group Study.一项针对晚期胰腺腺癌患者的大剂量24小时持续输注5-氟尿嘧啶、亚叶酸钙及低剂量丙氨酸磷酸核糖转移酶抑制剂的II期研究：一项西南肿瘤协作组研究
Invest New Drugs. 2004 Aug;22(3):335-41. doi: 10.1023/B:DRUG.0000026261.76197.54.
3
Preclinical development of eniluracil: enhancing the therapeutic index and dosing convenience of 5-fluorouracil.
Invest New Drugs. 2000 Nov;18(4):365-71. doi: 10.1023/a:1006401432488.
4
5-Fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development.5-氟尿嘧啶：四十余载仍在发挥作用。其临床前及临床开发综述
Invest New Drugs. 2000 Nov;18(4):299-313. doi: 10.1023/a:1006416410198.
5
Induction with mitomycin C, doxorubicin, cisplatin and maintenance with weekly 5-fluorouracil, leucovorin for treatment of metastatic nasopharyngeal carcinoma: a phase II study.丝裂霉素C、阿霉素、顺铂诱导化疗联合每周5-氟尿嘧啶、亚叶酸钙维持化疗治疗转移性鼻咽癌：一项II期研究
Br J Cancer. 1999 Aug;80(12):1962-7. doi: 10.1038/sj.bjc.6690627.
6
Resection of locally advanced pancreatic cancer after downstaging with continuous-infusion 5-fluorouracil, mitomycin-C, leucovorin, and dipyridamole.经持续输注5-氟尿嘧啶、丝裂霉素-C、亚叶酸钙和双嘧达莫进行降期后对局部进展期胰腺癌进行切除术。
J Gastrointest Surg. 1998 Mar-Apr;2(2):159-66. doi: 10.1016/s1091-255x(98)80008-5.
7
In vitro splicing of pre-messenger RNA with extracts from 5-fluorouridine-treated cells.利用来自5-氟尿苷处理细胞的提取物对信使前体RNA进行体外剪接。
Biochem J. 1994 Jan 15;297 ( Pt 2)(Pt 2):297-301. doi: 10.1042/bj2970297.
8
Weekly 5-fluorouracil and high-dose folinic acid in combination with epidoxorubicin as first-line therapy in advanced breast cancer: a phase II study.每周使用5-氟尿嘧啶和大剂量亚叶酸联合表柔比星作为晚期乳腺癌一线治疗的II期研究。
Cancer Chemother Pharmacol. 1994;34(1):75-8. doi: 10.1007/BF00686116.
9
Continuous 5-fluorouracil in the treatment of breast cancer.持续输注5-氟尿嘧啶治疗乳腺癌。
Br J Cancer. 1994 Jul;70(1):120-4. doi: 10.1038/bjc.1994.259.
10
Bolus/infusional 5-fluorouracil and folinic acid for metastatic colorectal carcinoma: are suboptimal dosages being used in the UK?大剂量注射/输注5-氟尿嘧啶和亚叶酸用于转移性结直肠癌：英国是否在使用次优剂量？
Br J Cancer. 1994 Oct;70(4):749-52. doi: 10.1038/bjc.1994.389.