Elenbaas R M
Am J Hosp Pharm. 1977 Aug;34(8):827-31.
A review of the proposed mechanisms of the disulfiram-alcohol interaction and recommended management of the interaction is presented. The efficacy of disulfiram in the management of alcoholism, the signs and symptoms of the disulfiram-alcohol interaction, and other agents with disulfiram-like activity are discussed. Recommended treatment consists of supportive measures such as Trendelenberg posture, administration of oxygen and intravenous infusion of fluid, solute, colloid, and, if needed, a pressor agent such as norepinephrine. Iron salts, ascorbic acid, antihistamines and phenothiazines are of no established benefit.
本文综述了双硫仑-酒精相互作用的潜在机制以及针对该相互作用的推荐处理方法。讨论了双硫仑在酒精中毒治疗中的疗效、双硫仑-酒精相互作用的体征和症状，以及其他具有双硫仑样活性的药物。推荐的治疗措施包括支持性措施，如头低脚高位、吸氧、静脉输注液体、溶质、胶体，必要时使用去甲肾上腺素等升压药。铁盐、抗坏血酸、抗组胺药和吩噻嗪类药物尚无确切疗效。
