Department of Pharmacy, Federal University of Sergipe, São Cristovão, Brazil.
Posgraduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristovão, Brazil.
Front Public Health. 2020 Oct 27;8:563095. doi: 10.3389/fpubh.2020.563095. eCollection 2020.
The emergence of a new coronavirus (SARS-CoV-2) outbreak represents a challenge for the diagnostic laboratories responsible for developing test kits to identify those infected with SARS-CoV-2. Methods with rapid and accurate detection are essential to control the sources of infection, to prevent the spread of the disease and to assist decision-making by public health managers. Currently, there is a wide variety of tests available with different detection methodologies, levels of specificity and sensitivity, detection time, and with an extensive range of prices. This review therefore aimed to conduct a patent search in relation to tests for the detection of SARS-CoV, MERS-CoV, and SARS-CoV-2. The greatest number of patents identified in the search were registered between 2003 and 2011, being mainly deposited by China, the Republic of Korea, and the United States. Most of the patents used the existing RT-PCR, ELISA, and isothermal amplification methods to develop simple, sensitive, precise, easy to use, low-cost tests that reduced false-negative or false-positive results. The findings of this patent search show that an increasing number of materials and diagnostic tests for the coronavirus are being produced to identify infected individuals and combat the growth of the current pandemic; however, there is still a question in relation to the reliability of the results of these tests.
一种新型冠状病毒(SARS-CoV-2)的爆发对负责开发用于识别 SARS-CoV-2 感染者的检测试剂盒的诊断实验室构成了挑战。具有快速和准确检测能力的方法对于控制感染源、防止疾病传播以及协助公共卫生管理人员做出决策至关重要。目前,有多种具有不同检测方法学、特异性和敏感性水平、检测时间的检测方法,价格也各不相同。因此,本综述旨在针对 SARS-CoV、MERS-CoV 和 SARS-CoV-2 的检测进行专利检索。在检索中发现的大多数专利是在 2003 年至 2011 年期间注册的,主要由中国、大韩民国和美国提交。大多数专利使用现有的 RT-PCR、ELISA 和等温扩增方法来开发简单、敏感、精确、易于使用、低成本的检测方法,从而减少假阴性或假阳性结果。这项专利检索的结果表明,为了识别感染者并对抗当前大流行的蔓延,越来越多的用于冠状病毒的材料和诊断检测正在被生产出来;然而,这些检测方法的结果的可靠性仍然存在疑问。
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