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中东呼吸综合征冠状病毒、严重急性呼吸综合征冠状病毒和严重急性呼吸综合征冠状病毒 2(COVID-19)诊断策略的趋势:专利述评。

Trends in MERS-CoV, SARS-CoV, and SARS-CoV-2 (COVID-19) Diagnosis Strategies: A Patent Review.

机构信息

Department of Pharmacy, Federal University of Sergipe, São Cristovão, Brazil.

Posgraduate Program in Pharmaceutical Sciences, Federal University of Sergipe, São Cristovão, Brazil.

出版信息

Front Public Health. 2020 Oct 27;8:563095. doi: 10.3389/fpubh.2020.563095. eCollection 2020.


DOI:10.3389/fpubh.2020.563095
PMID:33194964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7653175/
Abstract

The emergence of a new coronavirus (SARS-CoV-2) outbreak represents a challenge for the diagnostic laboratories responsible for developing test kits to identify those infected with SARS-CoV-2. Methods with rapid and accurate detection are essential to control the sources of infection, to prevent the spread of the disease and to assist decision-making by public health managers. Currently, there is a wide variety of tests available with different detection methodologies, levels of specificity and sensitivity, detection time, and with an extensive range of prices. This review therefore aimed to conduct a patent search in relation to tests for the detection of SARS-CoV, MERS-CoV, and SARS-CoV-2. The greatest number of patents identified in the search were registered between 2003 and 2011, being mainly deposited by China, the Republic of Korea, and the United States. Most of the patents used the existing RT-PCR, ELISA, and isothermal amplification methods to develop simple, sensitive, precise, easy to use, low-cost tests that reduced false-negative or false-positive results. The findings of this patent search show that an increasing number of materials and diagnostic tests for the coronavirus are being produced to identify infected individuals and combat the growth of the current pandemic; however, there is still a question in relation to the reliability of the results of these tests.

摘要

一种新型冠状病毒(SARS-CoV-2)的爆发对负责开发用于识别 SARS-CoV-2 感染者的检测试剂盒的诊断实验室构成了挑战。具有快速和准确检测能力的方法对于控制感染源、防止疾病传播以及协助公共卫生管理人员做出决策至关重要。目前,有多种具有不同检测方法学、特异性和敏感性水平、检测时间的检测方法,价格也各不相同。因此,本综述旨在针对 SARS-CoV、MERS-CoV 和 SARS-CoV-2 的检测进行专利检索。在检索中发现的大多数专利是在 2003 年至 2011 年期间注册的,主要由中国、大韩民国和美国提交。大多数专利使用现有的 RT-PCR、ELISA 和等温扩增方法来开发简单、敏感、精确、易于使用、低成本的检测方法,从而减少假阴性或假阳性结果。这项专利检索的结果表明,为了识别感染者并对抗当前大流行的蔓延,越来越多的用于冠状病毒的材料和诊断检测正在被生产出来;然而,这些检测方法的结果的可靠性仍然存在疑问。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac5/7653175/e283cbb7c473/fpubh-08-563095-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac5/7653175/d3b14c3720e3/fpubh-08-563095-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac5/7653175/e283cbb7c473/fpubh-08-563095-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac5/7653175/d3b14c3720e3/fpubh-08-563095-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac5/7653175/e283cbb7c473/fpubh-08-563095-g0002.jpg

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Trends in MERS-CoV, SARS-CoV, and SARS-CoV-2 (COVID-19) Diagnosis Strategies: A Patent Review.

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引用本文的文献

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Comparison of Four Active SARS-CoV-2 Surveillance Strategies in Representative Population Sample Points: Two-Factor Factorial Randomized Controlled Trial.

JMIR Public Health Surveill. 2023-8-17

[2]
What, Where, When and How of COVID-19 Patents Landscape: A Bibliometrics Review.

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[3]
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[4]
Estimated SARS-CoV-2 Infection and Seroprevalence in Firefighters from a Northeastern Brazilian State: A Cross-Sectional Study.

Int J Environ Res Public Health. 2021-8-1

[5]
Unknown Disease Outbreaks Detection: A Pilot Study on Feature-Based Knowledge Representation and Reasoning Model.

Front Public Health. 2021

[6]
Global landscape of patents related to human coronaviruses.

Int J Biol Sci. 2021-4-10

本文引用的文献

[1]
Human B Cell Clonal Expansion and Convergent Antibody Responses to SARS-CoV-2.

Cell Host Microbe. 2020-9-3

[2]
Molecular diagnostic technologies for COVID-19: Limitations and challenges.

J Adv Res. 2020-11

[3]
Structural basis of a shared antibody response to SARS-CoV-2.

Science. 2020-7-13

[4]
Laboratory diagnosis of coronavirus disease-2019 (COVID-19).

Clin Chim Acta. 2020-7-2

[5]
Analysis of adjunctive serological detection to nucleic acid test for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection diagnosis.

Int Immunopharmacol. 2020-6-26

[6]
Challenges in Laboratory Diagnosis of the Novel Coronavirus SARS-CoV-2.

Viruses. 2020-5-26

[7]
SARS, MERS and SARS-CoV-2 (COVID-19) treatment: a patent review.

Expert Opin Ther Pat. 2020-6-7

[8]
Diagnosis and treatment of coronavirus disease 2019 (COVID-19): Laboratory, PCR, and chest CT imaging findings.

Int J Surg. 2020-5-15

[9]
Reverse transcription recombinase-aided amplification assay combined with a lateral flow dipstick for detection of avian infectious bronchitis virus.

Poult Sci. 2019-12-30

[10]
A Peptide-Based Magnetic Chemiluminescence Enzyme Immunoassay for Serological Diagnosis of Coronavirus Disease 2019.

J Infect Dis. 2020-6-29

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