环状RNA：在癌症诊断与治疗中的新兴作用
Circular RNAs: Emerging Role in Cancer Diagnostics and Therapeutics.
作者信息
Rajappa Anuva, Banerjee Sucharita, Sharma Vivek, Khandelia Piyush
机构信息
Department of Biological Sciences, Birla Institute of Technology and Science, Pilani - Hyderabad Campus, Hyderabad, India.
出版信息
Front Mol Biosci. 2020 Oct 28;7:577938. doi: 10.3389/fmolb.2020.577938. eCollection 2020.
Circular RNAs (circRNAs) are rapidly coming to the fore as major regulators of gene expression and cellular functions. They elicit their influence a plethora of diverse molecular mechanisms. It is not surprising that aberrant circRNA expression is common in cancers and they have been implicated in multiple aspects of cancer pathophysiology such as apoptosis, invasion, migration, and proliferation. We summarize the emerging role of circRNAs as biomarkers and therapeutic targets in cancer.
环状RNA（circRNAs）正迅速成为基因表达和细胞功能的主要调节因子。它们通过多种不同的分子机制发挥作用。异常的circRNA表达在癌症中很常见，并且它们与癌症病理生理学的多个方面有关，如细胞凋亡、侵袭、迁移和增殖，这并不奇怪。我们总结了circRNAs作为癌症生物标志物和治疗靶点的新作用。
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