MDS and TP53: When One Hit Just Isn't Enough….
作者信息
Kent David G
机构信息
York Biomedical Research Institute, Department of Biology, University of York, York, UK.
出版信息
Hemasphere. 2020 Nov 6;4(6):e494. doi: 10.1097/HS9.0000000000000494. eCollection 2020 Dec.
Abstract
摘要
相似文献
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MDS and TP53: When One Hit Just Isn't Enough….骨髓增生异常综合征与TP53：当一次打击远远不够时……
Hemasphere. 2020 Nov 6;4(6):e494. doi: 10.1097/HS9.0000000000000494. eCollection 2020 Dec.
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Characterization of TP53 mutations in low-grade myelodysplastic syndromes and myelodysplastic syndromes with a non-complex karyotype.低级别骨髓增生异常综合征和非复杂核型骨髓增生异常综合征中 TP53 突变的特征。
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本文引用的文献
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Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes.TP53 等位基因状态对骨髓增生异常综合征的基因组稳定性、临床表现和预后的影响。
Nat Med. 2020 Oct;26(10):1549-1556. doi: 10.1038/s41591-020-1008-z. Epub 2020 Aug 3.
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Functional Classification of Mutations in Acute Myeloid Leukemia.急性髓系白血病中突变的功能分类
Cancers (Basel). 2020 Mar 10;12(3):637. doi: 10.3390/cancers12030637.
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Tracking hematopoietic stem cells and their progeny using whole-genome sequencing.利用全基因组测序追踪造血干细胞及其后代。
Exp Hematol. 2020 Mar;83:12-24. doi: 10.1016/j.exphem.2020.01.004. Epub 2020 Jan 30.
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Emerging single-cell tools are primed to reveal functional and molecular heterogeneity in malignant hematopoietic stem cells.新兴的单细胞工具正准备揭示恶性造血干细胞中的功能和分子异质性。
Curr Opin Hematol. 2019 Jul;26(4):214-221. doi: 10.1097/MOH.0000000000000512.
5
TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups.TP53 基因突变状态将复杂核型骨髓增生异常综合征分为不同的预后亚组。
Leukemia. 2019 Jul;33(7):1747-1758. doi: 10.1038/s41375-018-0351-2. Epub 2019 Jan 11.
6
Mutant p53 as a guardian of the cancer cell.突变型 p53 作为癌细胞的守护者。
Cell Death Differ. 2019 Jan;26(2):199-212. doi: 10.1038/s41418-018-0246-9. Epub 2018 Dec 11.
7
p53 in the DNA-Damage-Repair Process.DNA损伤修复过程中的p53
Cold Spring Harb Perspect Med. 2016 May 2;6(5):a026070. doi: 10.1101/cshperspect.a026070.
8
Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency.纯合子和杂合子 p53 基因敲除大鼠高频发生转移性肉瘤。
Am J Pathol. 2011 Oct;179(4):1616-22. doi: 10.1016/j.ajpath.2011.06.036. Epub 2011 Aug 18.
9
Clinical effect of point mutations in myelodysplastic syndromes.骨髓增生异常综合征点突变的临床疗效。
N Engl J Med. 2011 Jun 30;364(26):2496-506. doi: 10.1056/NEJMoa1013343.
10
p53 expression in myeloid cells of myelodysplastic syndromes. Association with evolution of overt leukemia.骨髓增生异常综合征髓系细胞中的p53表达。与明显白血病进展的关联。
Am J Pathol. 1994 Aug;145(2):338-44.
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