系统性红斑狼疮相关性视网膜血管炎用阿达木单抗治疗。
Systemic Lupus Erythematosus-associated Retinal Vasculitis Treated with Adalimumab.
机构信息
Emory Eye Center, Emory University School of Medicine, Atlanta, GA, USA.
Rheumatology, Piedmont Atlanta Hospital, Atlanta, GA, USA.
出版信息
Ocul Immunol Inflamm. 2022 May 19;30(4):981-985. doi: 10.1080/09273948.2020.1828937. Epub 2020 Nov 16.
PURPOSE
To present a case of refractory systemic lupus erythematosus (SLE)-associated retinal vasculitis that responded to the anti-tumor necrosis factor (TNF)-alpha inhibitor adalimumab as corticosteroid-sparing therapy.
METHODS
Descriptive case report of a patient with SLE with retinal vasculitis complicated by an ischemic retinal vein occlusion and cystoid macular edema.
RESULTS
A 30-year-old female patient with a history of SLE presented with retinal vasculitis and an ischemic, branch retinal vein occlusion with macular edema in the left eye. Oral corticosteroid was administered along with mycophenolate mofetil (MMF) as a corticosteroid-sparing agent. Despite MMF therapy, the patient developed an exacerbation of her vasculitis with the involvement of both eyes. Adalimumab was initiated with a resultant resolution of retinal vasculitis as a corticosteroid-sparing strategy with over 2 years of follow-up.
CONCLUSION
Anti-TNF-alpha therapy with adalimumab may be effective as a corticosteroid-sparing agent in select patients with ocular inflammation associated with SLE.
目的
介绍一例难治性系统性红斑狼疮（SLE）相关性视网膜血管炎病例，该病例对肿瘤坏死因子（TNF）-α抑制剂阿达木单抗（adalimumab）产生反应，作为皮质类固醇保眼治疗。
方法
对一例伴有视网膜血管炎、缺血性视网膜静脉阻塞和黄斑囊样水肿的 SLE 视网膜血管炎患者进行描述性病例报告。
结果
一名 30 岁女性患者，有 SLE 病史，左眼出现视网膜血管炎、缺血性、分支视网膜静脉阻塞伴黄斑水肿。给予口服皮质类固醇和霉酚酸酯（MMF）作为皮质类固醇保眼剂。尽管使用 MMF 治疗，但患者的血管炎仍加重，累及双眼。采用阿达木单抗进行治疗，作为皮质类固醇保眼策略，结果显示视网膜血管炎得到缓解，随访超过 2 年。
结论
抗 TNF-α 治疗，阿达木单抗可能对伴有 SLE 的眼部炎症的特定患者作为皮质类固醇保眼剂有效。
Zotero 插件