Jin Di, Liu Xun, Wang Yuwei, Fang Longjiang, Nie Weiduo, Li Chen, Li Sheng-Guang, Li Ming
Department of Rheumatology, Weifang People's Hospital, Weifang, Shandong, China.
Department of Ophthalmology, Weifang People's Hospital, Weifang, Shandong, China.
Front Immunol. 2025 Aug 18;16:1646850. doi: 10.3389/fimmu.2025.1646850. eCollection 2025.
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that can affect the ocular system, with retinal vasculitis and optic neuritis being rare but serious manifestations. We present a case of a 26-year-old female with newly diagnosed SLE who developed both retinal vasculitis and optic neuritis, leading to progressive visual impairment. She was successfully treated with methylprednisolone and rituximab, achieving significant visual recovery. A review of existing literature highlights the diagnostic challenges, pathophysiology, and optimal treatment strategies for such cases. Our findings emphasize the importance of early recognition and aggressive immunosuppressive therapy in improving patient outcomes.
系统性红斑狼疮(SLE)是一种多系统自身免疫性疾病,可累及眼部系统,视网膜血管炎和视神经炎虽罕见但为严重表现。我们报告一例26岁新诊断为SLE的女性患者,该患者同时发生了视网膜血管炎和视神经炎,导致视力进行性损害。她接受甲泼尼龙和利妥昔单抗治疗成功,视力显著恢复。对现有文献的回顾突出了此类病例的诊断挑战、病理生理学及最佳治疗策略。我们的研究结果强调了早期识别和积极免疫抑制治疗对改善患者预后的重要性。