J Drugs Dermatol. 2020 Nov 1;19(11):1030-1038. doi: 10.36849/JDD.2020.5117.
The aim of the study was to identify the effectiveness of the combination of tissue stabilized guided subcision, microfocused ultrasound, and minimally invasive calcium hydroxylapatite injections in various sequences for treating skin surface irregularities of the buttocks and thighs.
61 females (body mass index: 22.6 ± 2.4 kg/m², age: 37.2 ± 6.8 years) were enrolled in this randomized interventional prospective study. Treatment arms included a variable combination and sequence of three treatment modalities: (1) Tissue-stabilized guided subcision, (2) microfocused ultrasound, and (3) calcium hydroxylapatite injections. Six months after the final intervention skin laxity and skin dimpling severity scores were assessed by the study participants, the treating physicians and by eleven blinded independent board-certified experts.
No adverse events were observed during the study that required intervention outside the standard of care treatment protocol. The combination of three treatment modalities was shown to provide greater improvement in skin laxity 1.88 (95% CI, 0.66–5.37) and skin dimpling 1.31 (95% CI, 0.61–2.81) scores as compared to any combination of two modalities. The combination of concomitant microfocused ultrasound and calcium hydroxylapatite injections followed three months later by tissue stabilized guided subcision yielded the greatest improvement in skin laxity 2.23 (95% CI, 0.51–9.82) and skin dimpling 1.79 (95% CI, 0.67–4.78) at 9-month follow-up.
This study provides evidence for the effectiveness of combination therapies for the improvement of skin surface irregularities on the buttocks and thighs. J Drugs Dermatol. 2020;19(11): 1030-1038. doi:10.36849/JDD.2020.5117.
本研究旨在确定组织稳定引导下切开术、微聚焦超声和微创性羟基磷灰石注射相结合，以各种顺序治疗臀部和大腿皮肤表面不规则的有效性。
本随机介入前瞻性研究共纳入 61 名女性（体重指数：22.6±2.4kg/m²，年龄：37.2±6.8 岁）。治疗臂包括三种治疗方式的可变组合和顺序：（1）组织稳定引导下切开术，（2）微聚焦超声，和（3）羟基磷灰石注射。末次干预后 6 个月，由研究参与者、治疗医生和 11 名盲法独立认证专家评估皮肤松弛度和皮肤凹陷严重程度评分。
在研究过程中，未观察到需要在标准治疗方案之外进行干预的不良事件。与任何两种方式的组合相比，三种治疗方式的组合显示出在皮肤松弛度（1.88，95%置信区间：0.66–5.37）和皮肤凹陷（1.31，95%置信区间：0.61–2.81）评分方面有更大的改善。微聚焦超声和羟基磷灰石注射联合应用，随后三个月后再行组织稳定引导下切开术，在 9 个月随访时，皮肤松弛度（2.23，95%置信区间：0.51–9.82）和皮肤凹陷（1.79，95%置信区间：0.67–4.78）的改善最大。
本研究为臀部和大腿皮肤表面不规则的联合治疗提供了有效性证据。J 皮肤病学杂志。2020;19(11):1030-1038。doi:10.36849/JDD.2020.5117。
