Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.
Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Leicestershire, UK.
Osteoporos Int. 2021 May;32(5):907-919. doi: 10.1007/s00198-020-05714-4. Epub 2020 Nov 16.
We provided evidence that a 6-month regular hopping exercise intervention can increase trabecular number and possibly trabecular volume fraction of the distal tibia. Our novel localised analysis demonstrated region-specific changes, predominantly in the anterior region, in postmenopausal women.
The localisation of bone remodelling and microarchitectural adaptation to exercise loading has not been demonstrated previously in vivo in humans. The aim of this study is to assess the feasibility of using 3D image registration and high-resolution peripheral quantitative computed tomography (HR-pQCT) to investigate the effect of high-impact exercise on human trabecular bone variables and remodelling rate across the distal tibia.
Ten postmenopausal women were recruited for 6-month unilateral hopping exercises, with HR-pQCT scans taken of both exercise leg (EL) and control leg (CL) for each participant before and after the intervention. A 3D image registration was used to ensure measurements were taken at the same region. Short-term reproducibility tests were conducted prior to the assessment using identical setup. The results were assessed comparing CL and EL, and interaction (time × leg) using a two-way repeated measures analysis of variance (RM-ANOVA).
Across the whole tibia, we observed significant increases in trabecular number (Tb.N) (+ 4.4%) and trabecular bone formation rate (tBFR) (3.3%), and a non-significant increase in trabecular bone volume fraction (BV/TV) (+ 1%) in the EL. Regional resorption was higher in the CL than the EL, with this difference being statistically significant at the lateral tibia. In the EL, tBFR was significantly higher in the anterior region than the medial but a trabecular bone resorption rate (tBRR) showed no significant regional variation. Conversely in the CL, both tBFR and tBRR were significantly higher in the anterior and lateral than the medial region.
We demonstrated that it was possible to detect exercise-related bone adaptation with 3D registration of HR-pQCT scan data. Regular hopping exercise increased Tb.N and possibly BV/TV across the whole distal tibia. A novel finding of the study was that tBFR and tBRR responses to loading were localised: changes were achieved by formation rate exceeding resorption rate in the exercise leg, both globally and at the anterior region where turnover was greatest.
clinicaltrials.gov : NCT03225703.
本研究旨在评估使用 3D 图像配准和高分辨率外周定量 CT（HR-pQCT）来研究高强度冲击运动对人体胫骨远端小梁骨变量和改建率的影响的可行性。
招募了 10 名绝经后女性进行为期 6 个月的单侧跳跃运动，每位参与者在干预前后均对运动腿（EL）和对照腿（CL）进行 HR-pQCT 扫描。使用 3D 图像配准来确保在同一区域进行测量。在评估之前，使用相同的设置进行了短期可重复性测试。使用双向重复测量方差分析（RM-ANOVA）评估 CL 和 EL 之间以及（时间×腿）之间的交互作用的结果。
在整个胫骨中，我们观察到 EL 中骨小梁数量（Tb.N）增加了 4.4%，骨小梁形成率（tBFR）增加了 3.3%，骨小梁体积分数（BV/TV）增加了 1%。CL 中的骨小梁吸收率高于 EL，胫骨外侧的差异具有统计学意义。在 EL 中，tBFR 在前部区域明显高于内侧，但骨小梁吸收率（tBRR）没有明显的区域变化。相反，在 CL 中，前侧和外侧的 tBFR 和 tBRR 均明显高于内侧区域。
我们证明了通过 HR-pQCT 扫描数据的 3D 配准来检测与运动相关的骨适应性是可能的。定期跳跃运动增加了整个远端胫骨的 Tb.N 和可能的 BV/TV。本研究的一个新发现是，负荷引起的 tBFR 和 tBRR 反应是局部的：在运动腿中，形成率超过吸收率，从而导致全局和在前部区域（转换率最大）发生变化。
clinicaltrials.gov：NCT03225703。
