Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, Building 221, 2800 Kgs. Lyngby, Denmark.
J Nat Prod. 2020 Nov 25;83(11):3482-3491. doi: 10.1021/acs.jnatprod.0c00725. Epub 2020 Nov 16.
Azoxy compounds belong to a small yet intriguing group of natural products sharing a common functional group with the general structure RN═N(O)R. Their intriguing chemical structures, diverse biological activities, and important industrial applications have received attention from researchers in natural product chemistry, total synthesis, and biosynthesis. This review presents current updates about the structural diversity of natural azoxy compounds isolated from different organisms and highlights the enzymes and biological logic involved in their construction. We assume that the identification of key enzymes will provide efficient tools in biocatalysis to generate new azoxy compounds, while genome mining may result in novel natural azoxy compounds of medical and industrial interest.
偶氮化合物属于一类具有共同官能团 RN═N(O)R 的小型而有趣的天然产物，其结构多样，生物活性广泛，在天然产物化学、全合成和生物合成领域引起了研究人员的关注。本文综述了不同生物来源的天然偶氮化合物的结构多样性，并对其生物合成途径中涉及的酶和生物逻辑进行了重点介绍。我们假设关键酶的鉴定将为生物催化生成新型偶氮化合物提供有效的工具，而基因组挖掘可能会产生具有医学和工业价值的新型天然偶氮化合物。
