School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, U.K.
Nat Prod Rep. 2011 Aug;28(8):1426-44. doi: 10.1039/c1np00031d. Epub 2011 May 18.
Although diazo compounds are probably best known for their involvement as versatile intermediates in modern synthetic organic chemistry, a small number of such compounds also occur naturally. Many of the early examples, such as azaserine, originally isolated in the 1950s, have antitumour properties and consist of modified α-amino acids. More recently, other more complex diazo compounds have been isolated from natural sources, and these include diazobenzoquinones, diazonaphthoquinones, such as the SF2415 and A80915 antibiotics, and the diazofluorene-based kinamycins and lomaiviticins. This report will cover the isolation, biosynthesis, biological activity and synthesis of natural products containing a diazo group.
尽管重氮化合物因其作为现代合成有机化学中多功能中间体的作用而广为人知，但自然界中也存在少量此类化合物。许多早期的例子，如 azaserine，最初于 20 世纪 50 年代分离出来，具有抗肿瘤特性，由修饰的α-氨基酸组成。最近，其他更复杂的重氮化合物也已从天然来源中分离出来，其中包括 diazobenzoquinones、diazonaphthoquinones，如 SF2415 和 A80915 抗生素，以及基于 diazofluorene 的 kinamycins 和 lomaiviticins。本报告将涵盖含重氮基团的天然产物的分离、生物合成、生物活性和合成。
