通过不同肌肉测量方法评估慢性阻塞性肺疾病患者肌肉减少症的患病率：一项更新的荟萃分析和元回归分析
Prevalence of sarcopenia in patients with COPD through different musculature measurements: An updated meta-analysis and meta-regression.
作者信息
He Jie, Li Hezhi, Yao Jun, Wang Yan
机构信息
Clinical Medical College of Chengdu Medical College, Chengdu, Sichuan, China.
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
出版信息
Front Nutr. 2023 Feb 16;10:1137371. doi: 10.3389/fnut.2023.1137371. eCollection 2023.
AIM
Chronic obstructive pulmonary disease (COPD) patients vary widely in terms of the prevalence of sarcopenia, which is partially attributed to differences in diagnostic criteria and disease severity. There are several different musculature measurements that are used to quantify sarcopenia. This study included published literature for meta-analysis to assess the sarcopenia prevalence in COPD patients and correlate the disease with the clinical characteristics of such patients.
METHODS
A comprehensive review of the English and Chinese literature on sarcopenia prevalence in COPD patients was conducted using electronic databases such as China National Knowledge Infrastructure (CNKI), Web of Science, Cochrane Library, EMBASE, PubMed, and Wanfang. Two researchers analyzed the studies for Newcastle-Ottawa Scale. The software Stata 11.0 was employed for the analysis of the acquired data. The standard mean differences method was utilized for the estimation and quantification of the effect size. Furthermore, a fixed- or random-effects model was employed for conducting a combined analysis.
RESULTS
In total, 56 studies were included as per the specific inclusion criteria. The resulting data of the assessed COPD patients in this research indicated a 27% prevalence of sarcopenia. Further analysis of subgroups was executed per disease severity, ethnicity, diagnostic criteria, gender, and age. Per these findings, increased disease severity elevated the prevalence of sarcopenia. The Latin American and Caucasian populations indicated an increased prevalence of sarcopenia. In addition, the prevalence of sarcopenia was related to diagnostic criteria and definition. Male COPD patients had a higher prevalence of sarcopenia than female COPD patients. COPD patients with an average age greater than 65 had a slightly higher prevalence of sarcopenia. COPD patients with comorbid sarcopenia had poorer pulmonary function, activity tolerance, and clinical symptoms than patients with COPD alone.
CONCLUSION
Sarcopenia prevalence is high (27%) in COPD patients. In addition, these patients had worse pulmonary function and activity tolerance compared to patients without sarcopenia.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=367422, identifier CRD42022367422.
目的
慢性阻塞性肺疾病（COPD）患者的肌肉减少症患病率差异很大，部分原因是诊断标准和疾病严重程度不同。有几种不同的肌肉测量方法用于量化肌肉减少症。本研究纳入已发表的文献进行荟萃分析，以评估COPD患者的肌肉减少症患病率，并将该疾病与这类患者的临床特征相关联。
方法
使用中国知网（CNKI）、科学网、考克兰图书馆、EMBASE、PubMed和万方等电子数据库，对关于COPD患者肌肉减少症患病率的中英文文献进行全面综述。两名研究人员根据纽卡斯尔-渥太华量表对研究进行分析。使用Stata 11.0软件对获取的数据进行分析。采用标准平均差法估计和量化效应大小。此外，采用固定效应或随机效应模型进行合并分析。
结果
根据特定纳入标准，共纳入56项研究。本研究中评估的COPD患者的最终数据表明，肌肉减少症患病率为27%。根据疾病严重程度、种族、诊断标准、性别和年龄对亚组进行了进一步分析。根据这些结果，疾病严重程度增加会提高肌肉减少症的患病率。拉丁裔和白种人群的肌肉减少症患病率有所增加。此外，肌肉减少症的患病率与诊断标准和定义有关。男性COPD患者的肌肉减少症患病率高于女性COPD患者。平均年龄大于65岁的COPD患者的肌肉减少症患病率略高。合并肌肉减少症的COPD患者比单纯COPD患者的肺功能、活动耐力和临床症状更差。
结论
COPD患者的肌肉减少症患病率很高（27%）。此外，与没有肌肉减少症的患者相比，这些患者的肺功能和活动耐力更差。
系统评价注册
https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=367422，标识符CRD42022367422。
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