Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany,
Department of Ophthalmology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Ophthalmologica. 2021;244(2):133-140. doi: 10.1159/000513080. Epub 2020 Nov 16.
To investigate the incidence of retinal detachment in the German population and to assess potential risk factors.
The Gutenberg Health Study is a population-based cohort study in Mainz, Germany, including subjects (n = 15,010) with an age range from 35 to 74 years at baseline examination. Study participants underwent a comprehensive ophthalmological examination including distant-corrected visual acuity, refraction and slit-lamp examination at baseline examination. A computer-assisted telephone interview was conducted after 2.5 and 5 years, and health events were recorded. The 5-year cumulative incidence of retinal detachment was computed for the study sample and stratified on age decades. Risk factors were analyzed using logistic regression including age, sex, spherical equivalent, pseudophakia and prior laser retinal therapy.
13,416 participants (age 52.2 ± 10.7 years, 48.8% female) were included in this analysis. Twenty-eight subjects had a retinal detachment in one eye, no subject had a retinal detachment in both eyes. The 5-year cumulative incidence of retinal detachment was 0.21% (95% CI 0.14-0.31%), the incidence rate was 42/100,000 person-years. Risk factors were male sex (OR 4.16, p = 0.004), pseudophakia (OR 3.93, p = 0.045) and myopia (OR 1.31 per diopter myopia, p < 0.0001), but not prior retinal laser therapy or age.
The incidence of retinal detachment in Germany at the age of 35-74 years is comparable to estimates from neighboring European countries. Risk factors are male sex, pseudophakia and myopia.
调查德国人群中视网膜脱离的发生率，并评估潜在的危险因素。
哥廷根健康研究是德国美因茨的一项基于人群的队列研究，纳入了年龄在 35 至 74 岁之间的受试者（n=15010）。研究参与者在基线检查时接受了全面的眼科检查，包括远距校正视力、屈光度和裂隙灯检查。在 2.5 年和 5 年后进行了计算机辅助电话访谈，并记录了健康事件。对研究样本进行了视网膜脱离的 5 年累积发生率计算，并按年龄十年进行分层。使用逻辑回归分析包括年龄、性别、球镜等效、白内障和既往激光视网膜治疗在内的危险因素。
本分析纳入了 13416 名参与者（年龄 52.2±10.7 岁，48.8%为女性）。28 名受试者的一只眼发生了视网膜脱离，没有受试者双眼均发生视网膜脱离。视网膜脱离的 5 年累积发生率为 0.21%（95%CI 0.14-0.31%），发病率为 42/100000 人年。危险因素为男性（OR 4.16，p=0.004）、白内障（OR 3.93，p=0.045）和近视（每 1 屈光度近视的 OR 为 1.31，p<0.0001），但与既往视网膜激光治疗或年龄无关。
德国 35-74 岁人群的视网膜脱离发生率与邻国欧洲国家的估计值相当。危险因素为男性、白内障和近视。
