Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM) EA7424, Team "Vascular Biology and Red Blood Cell", Université Claude Bernard Lyon 1, Université de Lyon, Lyon, France.
Laboratoire d'Excellence du Globule Rouge (Labex GR-Ex), PRES Sorbonne, 75015 Paris, France.
Int J Mol Sci. 2020 Nov 12;21(22):8531. doi: 10.3390/ijms21228531.
Blood rheology is a key determinant of tissue perfusion at rest and during exercise. The present study investigated the effects of race distance on hematological, blood rheological, and red blood cell (RBC) senescence parameters. Eleven runners participated in the Martigny-Combes à Chamonix 40 km race (MCC, elevation gain: 2300 m) and 12 others in the Ultra-Trail du Mont Blanc (UTMB, 171 km, elevation gain: 10,000 m). Blood samples were collected before and after the races. After the UTMB, the percentage of RBC phosphatidylserine (PS) exposure was not affected while RBC CD235a levels decreased and RBC-derived microparticles increased. In contrast, after the MCC, RBC PS exposure increased, while RBC CD235a and RBC-derived microparticles levels were not affected. The free hemoglobin and hemolysis rate did not change during the races. RBC aggregation and blood viscosity at moderate shear rates increased after the MCC. RBC deformability, blood viscosity at a high shear rate, and hematocrit decreased after the UTMB but not after the MCC. Our results indicate that blood rheology behavior is different between a 40 km and a 171 km mountain race. The low blood viscosity after the ultra-marathon might facilitate blood flow to the muscles and optimize aerobic performance.
血液流变性是静息和运动时组织灌注的关键决定因素。本研究探讨了比赛距离对血液学、血液流变性和红细胞（RBC）衰老参数的影响。11 名跑步者参加了马蒂尼-孔布兹到夏蒙尼 40 公里比赛（MCC，海拔升高：2300 米），另有 12 名跑步者参加了环勃朗峰超级越野赛（UTMB，171 公里，海拔升高：10000 米）。在比赛前后采集了血液样本。在 UTMB 之后，RBC 磷脂酰丝氨酸（PS）暴露的百分比没有受到影响，而 RBC CD235a 水平下降，RBC 衍生的微粒增加。相比之下，在 MCC 之后，RBC PS 暴露增加，而 RBC CD235a 和 RBC 衍生的微粒水平不受影响。在比赛过程中，游离血红蛋白和溶血率没有变化。在 MCC 之后，RBC 聚集和中等剪切速率下的血液粘度增加。在 UTMB 之后，RBC 变形性、高剪切率下的血液粘度和血细胞比容降低，但在 MCC 之后没有降低。我们的结果表明，40 公里和 171 公里山地比赛之间的血液流变性行为不同。超长马拉松赛后的低血液粘度可能有利于肌肉血流，优化有氧表现。
Zotero 插件
