疾病相关丙烯醛：体内合成化学的潜在诊断和治疗底物。
Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry.
机构信息
Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, 1-12-1, Ookayama, Meguro-ku, Tokyo 152-8552, Japan.
Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, 1-12-1, Ookayama, Meguro-ku, Tokyo 152-8552, Japan; Biofunctional Synthetic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan; Biofunctional Chemistry Laboratory, A. Butlerov Institute of Chemistry, Kazan Federal University, 18 Kremlyovskaya Street, Kazan 420008, Russia.
出版信息
Bioorg Med Chem. 2020 Dec 15;28(24):115831. doi: 10.1016/j.bmc.2020.115831. Epub 2020 Oct 31.
Acrolein, a highly reactive α,β-unsaturated aldehyde, is a compound to which humans are exposed in many different situations and often causes various human diseases. This paper summarizes the reports over the past twenty-five years regarding disease-associated acrolein detected in clinical patients and the role acrolein plays in various diseases. In several diseases, it was found that the increased acrolein acts as a pathogenetic factor. Thus, we propose the utility of over-produced acrolein as a substrate for a promising therapeutic or diagnostic method applicable to a wide range of diseases based on an in vivo synthetic chemistry strategy.
丙烯醛是一种具有高反应性的α,β-不饱和醛，是人类在许多不同情况下接触到的一种化合物，经常导致各种人类疾病。本文总结了过去二十五年间有关在临床患者中检测到与疾病相关的丙烯醛的报告，以及丙烯醛在各种疾病中所起的作用。在几种疾病中，发现增加的丙烯醛作为一种发病因素。因此，我们提出将过量产生的丙烯醛作为一种有前途的治疗或诊断方法的底物的应用，该方法基于体内合成化学策略，适用于广泛的疾病。
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