Institute of Biology/Microbiology, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany
J Bacteriol. 2021 Jan 11;203(3). doi: 10.1128/JB.00595-20.
Although mechanistic understanding of calcium signaling in bacteria remains inchoate, current evidence clearly links Ca signaling with membrane potential and mechanosensation. Adopting a radically new approach, Luder et al. scanned the Keio collection of gene knockouts (R. Luder, G. N. Bruni, and J. M. Kralj, J Bacteriol 203:e00509-20, 2021, https://doi.org/10.1128/JB.00509-20) to identify mutations that cause changes in Ca transients. They identify genes associating Ca signaling with outer membrane biogenesis, proton motive force, and, surprisingly, long-term DNA damage. Their work has major implications for electrophysiological communication between bacteria and their environment.
尽管细菌中钙信号传导的机制理解仍处于初级阶段，但目前的证据清楚地将 Ca 信号与膜电位和机械感觉联系起来。Ludere 等人采用一种全新的方法，扫描 Keio 基因敲除文库（R. Luder、G. N. Bruni 和 J. M. Kralj，J Bacteriol 203:e00509-20, 2021, https://doi.org/10.1128/JB.00509-20），以鉴定导致 Ca 瞬变变化的突变。他们鉴定出与外膜生物发生、质子动力势相关的基因，以及令人惊讶的是，与长期 DNA 损伤相关的基因。他们的工作对细菌与其环境之间的电生理通讯具有重大影响。
