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使用合成代谢雄激素类固醇导致的迟发性横纹肌溶解症。

Delayed rhabdomyolysis secondary to anabolic-androgenic steroid use.

机构信息

West Middlesex University Hospital, Isleworth, UK

West Middlesex University Hospital, Isleworth, UK.

出版信息

Clin Med (Lond). 2020 Nov;20(6):e260-e261. doi: 10.7861/clinmed.2020-0694.

DOI:10.7861/clinmed.2020-0694
PMID:33199332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7687328/
Abstract

There are literature reports of anabolic-androgenic steroid-induced rhabdomyolysis. Here we describe a case of a patient presenting with acute confusion and rhabdomyolysis, following an unwitnessed seizure. He had a background of alcohol excess. Three days into his admission he developed dysphagia. At first, the patient denied the use of any medication or drugs. However, he later revealed he had used the anabolic steroid 'Anavar' (oxandrolone) for 60 consecutive days ending a month prior to his admission. The brief seizure was itself unlikely to have resulted in the severity of his rhabdomyolysis. Thus, we report a likely case of delayed rhabdomyolysis secondary to anabolic steroid use. The oropharyngeal dysphagia may be secondary to the rhabdomyolysis; there have been cases of this described in literature.

摘要

有文献报道称,合成代谢雄激素类固醇可导致横纹肌溶解症。在这里,我们描述了一例患者,在未被目击的癫痫发作后,出现急性意识混乱和横纹肌溶解症。该患者有酗酒史。入院 3 天后,他出现吞咽困难。起初,患者否认使用任何药物或毒品。然而,他后来透露他曾使用过合成代谢类固醇 'Anavar'(氧雄龙),连续使用了 60 天,在入院前一个月结束。短暂的癫痫发作本身不太可能导致他的横纹肌溶解症如此严重。因此,我们报告了一例可能由于使用合成代谢类固醇导致的迟发性横纹肌溶解症。口咽性吞咽困难可能是由于横纹肌溶解症引起的;文献中有过这种情况的描述。

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The efficacy and safety of oxandrolone treatment for patients with severe burns: A systematic review and meta-analysis.氧雄龙治疗重度烧伤患者的疗效和安全性:一项系统评价和荟萃分析。
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Anabolic androgenic steroid induced necrotising myopathy.雄激素性合成代谢类固醇引起的坏死性肌病。
Rheumatol Int. 2011 Jul;31(7):915-7. doi: 10.1007/s00296-009-1235-6. Epub 2009 Oct 27.
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