在从人类微生物群中分离的细菌物种中发现了一种新的磷霉素耐药基因家族。
, a New Family of Fosfomycin Resistance Genes Identified in Bacterial Species Isolated from Human Microbiota.
机构信息
Aix Marseille University, IRD, APHM, MEPHI, IHU Méditerranée Infection, Marseille, France.
Aix Marseille University, IRD, APHM, MEPHI, IHU Méditerranée Infection, Marseille, France
出版信息
Antimicrob Agents Chemother. 2021 Jan 20;65(2). doi: 10.1128/AAC.01712-20.
Abstract
Fosfomycin is a decades-old antibiotic, currently reused because of its activity against multidrug-resistant bacteria. Here, we used a combined approach to search for fosfomycin resistance determinants in 25 new bacterial species isolated from the human microbiota. Putative resistance genes were cloned into a susceptible strain. MIC values increased from 1 μg/ml to 1,024 μg/ml. Here, we report a new family of potential chromosomal fosfomycin resistance genes, named .
摘要
磷霉素是一种有几十年历史的抗生素，由于其对多种耐药菌的活性，目前正在重新使用。在这里，我们使用联合方法在从人体微生物群中分离的 25 种新细菌物种中寻找磷霉素耐药决定因素。推定的耐药基因被克隆到敏感菌株中。MIC 值从 1μg/ml 增加到 1024μg/ml。在这里，我们报告了一种新的潜在染色体磷霉素耐药基因家族，命名为.
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