Aix Marseille University, IRD, APHM, MEPHI, IHU Méditerranée Infection, Marseille, France.
Aix Marseille University, IRD, APHM, MEPHI, IHU Méditerranée Infection, Marseille, France
Antimicrob Agents Chemother. 2021 Jan 20;65(2). doi: 10.1128/AAC.01712-20.
Fosfomycin is a decades-old antibiotic, currently reused because of its activity against multidrug-resistant bacteria. Here, we used a combined approach to search for fosfomycin resistance determinants in 25 new bacterial species isolated from the human microbiota. Putative resistance genes were cloned into a susceptible strain. MIC values increased from 1 μg/ml to 1,024 μg/ml. Here, we report a new family of potential chromosomal fosfomycin resistance genes, named .
磷霉素是一种有几十年历史的抗生素，由于其对多种耐药菌的活性，目前正在重新使用。在这里，我们使用联合方法在从人体微生物群中分离的 25 种新细菌物种中寻找磷霉素耐药决定因素。推定的耐药基因被克隆到敏感菌株中。MIC 值从 1μg/ml 增加到 1024μg/ml。在这里，我们报告了一种新的潜在染色体磷霉素耐药基因家族，命名为.
