利福平、利福喷汀和利福布汀对与人工关节假体感染相关的表皮葡萄球菌的胞内感染有活性。
Rifampin, Rifapentine, and Rifabutin Are Active against Intracellular Periprosthetic Joint Infection-Associated Staphylococcus epidermidis.
机构信息
Mayo Clinic Graduate School of Biomedical Sciences, Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA.
Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
出版信息
Antimicrob Agents Chemother. 2021 Jan 20;65(2). doi: 10.1128/AAC.01275-20.
Abstract
is a major cause of periprosthetic joint infection (PJI); its intracellular persistence within osteoblasts may compromise therapy if that therapy is not intracellularly active. The intracellular activity of rifampin, rifapentine, and rifabutin was assessed against five rifampin-susceptible and two rifampin-resistant isolates. Compared to no treatment, treatment resulted in a ≥2-fold log reduction of intracellular rifampin-susceptible, but not rifampin-resistant, These findings show activity of rifampin, rifapentine, and rifabutin against intraosteoblast PJI-associated .
摘要
是假体周围关节感染（PJI）的主要原因；如果治疗药物对细胞内无效，其在成骨细胞内的持续存在可能会影响治疗效果。本研究评估了利福平、利福喷丁和利福布汀对 5 株利福平敏感和 2 株利福平耐药分离株的细胞内活性。与未治疗相比，治疗导致细胞内利福平敏感但不敏感的利福平耐药的对数减少≥2 倍。这些发现表明利福平、利福喷丁和利福布汀对骨内 PJI 相关的具有活性。
相似文献
1
Rifampin, Rifapentine, and Rifabutin Are Active against Intracellular Periprosthetic Joint Infection-Associated Staphylococcus epidermidis.利福平、利福喷汀和利福布汀对与人工关节假体感染相关的表皮葡萄球菌的胞内感染有活性。
Antimicrob Agents Chemother. 2021 Jan 20;65(2). doi: 10.1128/AAC.01275-20.
2
Activity of Rifampin, Rifabutin, and Rifapentine against Enterococci and Streptococci from Periprosthetic Joint Infection.利福平、利福布汀和利福喷汀对人工关节感染中肠球菌和链球菌的活性
Microbiol Spectr. 2021 Sep 3;9(1):e0007121. doi: 10.1128/Spectrum.00071-21. Epub 2021 Jul 14.
3
Activity of Rifampin, Rifabutin, Rifapentine, and Rifaximin against Planktonic and Biofilm States of Staphylococci Isolated from Periprosthetic Joint Infection.利福平、利福布汀、利福喷汀和利福昔明对来自人工关节感染的浮游和生物膜状态葡萄球菌的活性。
Antimicrob Agents Chemother. 2019 Oct 22;63(11). doi: 10.1128/AAC.00959-19. Print 2019 Nov.
4
Novel Use of Rifabutin and Rifapentine to Treat Methicillin-Resistant Staphylococcus aureus in a Rat Model of Foreign Body Osteomyelitis.利福布汀和利福喷汀治疗异物性骨髓炎大鼠模型耐甲氧西林金黄色葡萄球菌感染的新用途。
J Infect Dis. 2020 Oct 1;222(9):1498-1504. doi: 10.1093/infdis/jiaa401.
5
Rifamycin resistance, rpoB gene mutation and clinical outcomes of Staphylococcus species isolates from prosthetic joint infections in Republic of Korea.韩国人工关节感染分离的葡萄球菌属菌株的利福霉素耐药性、rpoB 基因突变与临床结局
J Glob Antimicrob Resist. 2022 Mar;28:43-48. doi: 10.1016/j.jgar.2021.12.005. Epub 2021 Dec 14.
6
Genomics of Staphylococcus aureus and Staphylococcus epidermidis from Periprosthetic Joint Infections and Correlation to Clinical Outcome.假体周围关节感染的金黄色葡萄球菌和表皮葡萄球菌的基因组学及其与临床结果的相关性。
Microbiol Spectr. 2022 Aug 31;10(4):e0218121. doi: 10.1128/spectrum.02181-21. Epub 2022 Jun 28.
7
In vitro activity of oritavancin in combination with rifampin or gentamicin against prosthetic joint infection-associated methicillin-resistant Staphylococcus epidermidis biofilms.利奈唑胺与替考拉宁治疗金黄色葡萄球菌感染的临床疗效与安全性的meta 分析
Int J Antimicrob Agents. 2018 Nov;52(5):608-615. doi: 10.1016/j.ijantimicag.2018.07.012. Epub 2018 Jul 24.
8
Staphylococcus lugdunensis, a serious pathogen in periprosthetic joint infections: comparison to Staphylococcus aureus and Staphylococcus epidermidis.路邓葡萄球菌，人工关节周围感染中的一种严重病原体：与金黄色葡萄球菌和表皮葡萄球菌的比较。
Int J Infect Dis. 2016 Oct;51:56-61. doi: 10.1016/j.ijid.2016.08.007. Epub 2016 Sep 5.
9
Efficacy of rifapentine and other rifamycins against .利福喷丁和其他利福霉素类药物对 的疗效。
Microbiol Spectr. 2024 Jul 2;12(7):e0103424. doi: 10.1128/spectrum.01034-24. Epub 2024 Jun 12.
10
Uptake and activity of rifapentine in human peritoneal macrophages and polymorphonuclear leukocytes.利福喷丁在人腹膜巨噬细胞和多形核白细胞中的摄取及活性
Eur J Clin Microbiol. 1987 Apr;6(2):152-7. doi: 10.1007/BF02018197.
引用本文的文献
1
Combination Antibiotic Therapy for Orthopedic Infections.用于骨科感染的联合抗生素治疗
Antibiotics (Basel). 2025 Jul 29;14(8):761. doi: 10.3390/antibiotics14080761.
2
Should We Use Rifampicin in Periprosthetic Joint Infections Caused by Staphylococci When the Implant Has Been Exchanged? A Multicenter Observational Cohort Study.当植入物已更换时，我们是否应在葡萄球菌引起的人工关节感染中使用利福平？一项多中心观察性队列研究。
Open Forum Infect Dis. 2023 Oct 6;10(10):ofad491. doi: 10.1093/ofid/ofad491. eCollection 2023 Oct.
3
Activity of Omadacycline in Rat Methicillin-Resistant Staphylococcus aureus Osteomyelitis.奥马环素在大鼠耐甲氧西林金黄色葡萄球菌骨髓炎中的活性。
Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0170321. doi: 10.1128/AAC.01703-21. Epub 2021 Nov 1.
4
Staphylococcal trafficking and infection-from 'nose to gut' and back.葡萄球菌的传播和感染——从“鼻子到肠道”再到返回。
FEMS Microbiol Rev. 2022 Jan 18;46(1). doi: 10.1093/femsre/fuab041.
本文引用的文献
1
Novel Use of Rifabutin and Rifapentine to Treat Methicillin-Resistant Staphylococcus aureus in a Rat Model of Foreign Body Osteomyelitis.利福布汀和利福喷汀治疗异物性骨髓炎大鼠模型耐甲氧西林金黄色葡萄球菌感染的新用途。
J Infect Dis. 2020 Oct 1;222(9):1498-1504. doi: 10.1093/infdis/jiaa401.
2
Antibiofilm and intraosteoblastic activities of rifamycins against Staphylococcus aureus: promising in vitro profile of rifabutin.利福霉素类药物对金黄色葡萄球菌的抗生物膜和骨内活性：利福布汀具有有前景的体外特性。
J Antimicrob Chemother. 2020 Jun 1;75(6):1466-1473. doi: 10.1093/jac/dkaa061.
3
Duration of rifampin therapy is a key determinant of improved outcomes in early-onset acute prosthetic joint infection due to treated with a debridement, antibiotics and implant retention (DAIR): a retrospective multicenter study in France.利福平治疗持续时间是清创、抗生素和植入物保留（DAIR）治疗早发性急性人工关节感染改善预后的关键决定因素：法国一项回顾性多中心研究。
J Bone Jt Infect. 2020 Feb 10;5(1):28-34. doi: 10.7150/jbji.40333. eCollection 2020.
4
Activity of Rifampin, Rifabutin, Rifapentine, and Rifaximin against Planktonic and Biofilm States of Staphylococci Isolated from Periprosthetic Joint Infection.利福平、利福布汀、利福喷汀和利福昔明对来自人工关节感染的浮游和生物膜状态葡萄球菌的活性。
Antimicrob Agents Chemother. 2019 Oct 22;63(11). doi: 10.1128/AAC.00959-19. Print 2019 Nov.
5
Survival of Staphylococcus epidermidis in Fibroblasts and Osteoblasts.表皮葡萄球菌在成纤维细胞和骨细胞中的存活。
Infect Immun. 2018 Sep 21;86(10). doi: 10.1128/IAI.00237-18. Print 2018 Oct.
6
Rifampicin resistance in Staphylococcus epidermidis: molecular characterisation and fitness cost of rpoB mutations.表皮葡萄球菌利福平耐药性：rpoB 突变的分子特征和适应代价。
Int J Antimicrob Agents. 2018 May;51(5):670-677. doi: 10.1016/j.ijantimicag.2017.12.019. Epub 2017 Dec 26.
7
Rifamycin Derivatives Are Effective Against Staphylococcal Biofilms In Vitro and Elutable From PMMA.利福霉素衍生物在体外对葡萄球菌生物膜有效，且可从聚甲基丙烯酸甲酯中洗脱。
Clin Orthop Relat Res. 2015 Sep;473(9):2874-84. doi: 10.1007/s11999-015-4300-3.
8
Intracellular proliferation of S. aureus in osteoblasts and effects of rifampicin and gentamicin on S. aureus intracellular proliferation and survival.金黄色葡萄球菌在成骨细胞内的增殖以及利福平与庆大霉素对金黄色葡萄球菌细胞内增殖和存活的影响。
Eur Cell Mater. 2014 Oct 23;28:258-68. doi: 10.22203/ecm.v028a18.
9
Prosthetic joint infection.人工关节感染
Clin Microbiol Rev. 2014 Apr;27(2):302-45. doi: 10.1128/CMR.00111-13.
10
Staphylococcus epidermidis in orthopedic device infections: the role of bacterial internalization in human osteoblasts and biofilm formation.表皮葡萄球菌引起的骨科器械感染：细菌内化在人成骨细胞和生物膜形成中的作用。
PLoS One. 2013 Jun 28;8(6):e67240. doi: 10.1371/journal.pone.0067240. Print 2013.
Zotero 插件