Institute of Cardiovascular Research, Royal Holloway University of London, Egham, UK.
Department of Clinical Neuroscience, Imperial College Healthcare NHS Trust, London, UK.
BMJ Open. 2020 Nov 16;10(11):e042090. doi: 10.1136/bmjopen-2020-042090.
To describe the characteristics and outcomes of hospitalised patients with COVID-19 from UK in the highest decile of health and gross regional products per capita.
Prospective cohort study.
Recruited all adult inpatients with laboratory-confirmed COVID-19 symptoms admitted to a single Surrey centre between March and April 2020. Extensive demographic details were documented.
COVID-19 status of alive/dead and intensive care unit (ICU) status of yes/no.
Patients with COVID-19 from Surrey centre UK (n=429).
429 adult inpatients (mean age 70±18 years; men 56.4%) were included in this study, of whom, 19.1% required admission to ICU and 31.9% died. Adverse outcomes were associated with age (OR with each decade of years: 1.78, 95% CI 1.53 to 2.11, p<0.001 for mortality); male gender (OR=1.08, 95% CI 0.72 to 1.63, p=0.72, present in 70.7%, of admissions to ICU versus 53% of other cases, p=0.004); cardiac disease (OR=3.43, 95% CI 2.10 to 5.63, p<0.001), diabetes mellitus (OR=2.37, 95% CI 1.09 to 5.17, p=0.028) and dementia (OR=5.06, 95% CI 2.79 to 9.44, p<0.001). There was no significant impact of ethnicity or body mass index on disease outcome.
Despite reports of worse outcomes in deprived regions, we show similar complication and mortality rates due to COVID-19 in an affluent and high life expectancy region.
描述英国人均卫生保健支出和地区生产总值最高十分位数的住院 COVID-19 患者的特征和结局。
前瞻性队列研究。
2020 年 3 月至 4 月期间，招募了英国萨里中心所有因实验室确诊的 COVID-19 症状而住院的成年住院患者。记录了广泛的人口统计学细节。
COVID-19 患者的存活/死亡状态和重症监护病房（ICU）入住状态。
来自英国萨里中心的 COVID-19 患者（n=429）。
本研究共纳入 429 名成年住院患者（平均年龄 70±18 岁；男性占 56.4%），其中 19.1%需要入住 ICU，31.9%死亡。不良结局与年龄相关（每十年的风险比：1.78，95%置信区间 1.53 至 2.11，p<0.001 与死亡率相关）；男性（OR=1.08，95%置信区间 0.72 至 1.63，p=0.72，入住 ICU 的病例中占 70.7%，而其他病例中占 53%，p=0.004）；心脏病（OR=3.43，95%置信区间 2.10 至 5.63，p<0.001）、糖尿病（OR=2.37，95%置信区间 1.09 至 5.17，p=0.028）和痴呆（OR=5.06，95%置信区间 2.79 至 9.44，p<0.001）。种族或体重指数对疾病结局没有显著影响。
尽管有报道称贫困地区的结局更差，但我们在一个富裕且预期寿命较高的地区发现了 COVID-19 导致的类似并发症和死亡率。
