Ken-Dror Gie, Wade Charles, Sharma Shyam S, Irvin-Sellers Melanie, Robin Jonathan, Fluck David, Bentley Paul, Sharma Pankaj
Institute of Cardiovascular Research, Royal Holloway University of London, Egham UK.
Imperial College NHS Healthcare Trust, London.
Clin Med (Lond). 2021 May;21(3):e290-e294. doi: 10.7861/clinmed.2020-1096. Epub 2021 Mar 23.
We determined the seroprevalence of SARS-CoV-2 antibodies in NHS healthcare workers (HCWs) in a cross-sectional study from a large general hospital located in a double-sited rural and semi-rural area. The sample size of 3,119 HCWs (mean age 43±13) consisted of 75.2% women, 61.1% White individuals and predominantly (62.4%) asymptomatic individuals. Seroprevalence of SARS-CoV-2 antibodies was 19.7%. Determinants of seropositivity were preceding symptomatic infection and non-White ethnicity. Regardless of staff role or sex, multivariate regression analysis revealed that non-White HCWs were three times (odds ratio [OR] 3.12, 95% confidence interval [CI] 2.53-3.86, P<0.001) more likely to have antibodies than White staff, and seven times (OR 7.10, 95% CI 5.72-8.87, P<0.001) more likely if there was a history of preceding symptoms. We report relatively high rates of seropositivity in all NHS healthcare workers. Non-White symptomatic HCWs were significantly more likely to be seropositive than their colleagues, independent of age, sex or staff role.
在一项横断面研究中，我们对位于农村和半农村双地点的一家大型综合医院的英国国家医疗服务体系（NHS）医护人员（HCWs）的新冠病毒（SARS-CoV-2）抗体血清阳性率进行了测定。3119名医护人员（平均年龄43±13岁）组成了样本，其中女性占75.2%，白人占61.1%，且主要为（62.4%）无症状个体。SARS-CoV-2抗体血清阳性率为19.7%。血清阳性的决定因素是先前有症状的感染和非白人种族。无论工作人员的角色或性别如何，多因素回归分析显示，非白人医护人员拥有抗体的可能性是白人工作人员的三倍（优势比[OR]3.12，95%置信区间[CI]2.53 - 3.86，P<0.001），如果有先前症状史，则可能性高七倍（OR 7.10，95% CI 5.72 - 8.87，P<0.001）。我们报告了所有NHS医护人员相对较高的血清阳性率。有症状的非白人医护人员比其同事血清呈阳性的可能性显著更高，与年龄、性别或工作人员角色无关。
