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[泛发性脓疱型银屑病——分类、临床特征及治疗。18例患者的回顾与经验]

[Psoriasis pustulosa generalisata--classification, clinical aspects and therapy. Review and experiences with 18 patients].

作者信息

Braun-Falco O, Berthold D, Ruzicka T

机构信息

Dermatologische Klinik, Ludwig-Maximilians-Universität München.

出版信息

Hautarzt. 1987 Sep;38(9):509-20.

PMID:3319966
Abstract

On the basis of clinico-morphological criteria we suggest the following classification of various pustular forms of psoriasis into four subtypes: generalized pustular psoriasis (von Zumbusch) and its atypical forms, erythema anulare centrifugum-like psoriasis with and without pustulation (EACP); psoriasis vulgaris with pustulation; palmo-plantar pustular psoriasis (Königsbeck-Barber) and its acral variant; acrodermatitis continua suppurativa (Hallopeau), and transitional forms. This classification takes into consideration both clinical aspects and response to treatment, and allows a prognosis of the various types of pustular psoriasis. Owing to its mild course and good treatment results, EACP represents a special form of psoriasis pustulosa generalisata. In our group of patients, systemic glucocorticosteroid therapy has proved deleterious, whereas oral photochemotherapy and etretinate have been found to be highly effective modes of therapy with only mild side effects and have been able to induce even permanent remission in EACP.

摘要

基于临床形态学标准,我们建议将各种脓疱型银屑病分为以下四个亚型:泛发性脓疱型银屑病(冯·祖姆布施型)及其非典型形式、有脓疱和无脓疱的离心性环状红斑样银屑病(EACP);有脓疱的寻常型银屑病;掌跖脓疱型银屑病(柯尼希斯贝克-巴伯型)及其肢端型;连续性肢端皮炎(哈洛佩型)以及过渡形式。这种分类兼顾了临床方面和对治疗的反应,并能对各种类型的脓疱型银屑病进行预后评估。由于其病程较轻且治疗效果良好,EACP代表了泛发性脓疱型银屑病的一种特殊形式。在我们的患者群体中,全身糖皮质激素治疗已被证明有害,而口服光化学疗法和依曲替酯已被发现是高效的治疗方式,副作用轻微,甚至能够使EACP达到永久缓解。

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