SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilapsur, CG, India.
Nanomedicine and Bioengineering Research Laboratory, Department of Pharmacy, Indira Gandhi National Tribal University, Amarkantak, MP, India.
Curr Pharm Des. 2020;26(42):5503-5517. doi: 10.2174/1381612826666201116120422.
Nanotheranostics, an approach of combining both diagnosis and therapy, is one of the latest advances in cancer therapy particularly. Nanocarriers designed and derived from inorganic materials such as like gold nanoparticles, silica nanoparticles, magnetic nanoparticles and carbon nanotubes have been explored for tremendous applications in this area. Similarly, nanoparticles composed of some organic material alone or in combination with inorganic nano-cargos have been developed pre-clinically and possess excellent features desired. Photothermal therapy, MRI, simultaneous imaging and delivery, and combination chemotherapy with a diagnosis are a few of the known methods exploring cancer therapy and detection at organ/tissue/molecular/sub-cellular level. This review comprises an overview of the recent reports meant for nano theranostics purposes. Targeted cancer nanotheranostics have been included for understating tumor micro-environment or cell-specific targeting approach employed. A brief account of various strategies is also included for the readers highlighting the mechanism of cancer therapy.
纳米诊疗一体，即将诊断与治疗结合的一种方法，是癌症治疗领域的最新进展之一。由无机材料（如金纳米粒子、硅纳米粒子、磁性纳米粒子和碳纳米管）设计和衍生的纳米载体已在该领域的众多应用中得到探索。同样，由一些有机材料单独或与无机纳米载体组合而成的纳米粒子已在临床前得到开发，并具有优异的所需特性。光热疗法、磁共振成像、同时成像和递药以及联合化疗与诊断是一些已知的探索癌症治疗和在器官/组织/分子/亚细胞水平检测的方法。这篇综述概述了最近为纳米诊疗一体目的而进行的报告。已纳入针对癌症的靶向纳米诊疗一体，以了解肿瘤微环境或细胞特异性靶向方法。还简要介绍了各种策略，为读者突出癌症治疗的机制。
