Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, India.
Mini Rev Med Chem. 2021;21(6):731-737. doi: 10.2174/1389557520666201116144421.
Cancer is a deadly disease, which has significantly increased in both developed and developing nations. Treatment of cancer utilizing radiotherapy or chemotherapy actuates a few issues which incorporate spewing, sickness, unpalatable reactions, and so forth. In this specific situation, an alternative drug source, which can effectively treat cancer is of prime importance. Products that are obtained from plant sources are utilized for the treatment of various diseases due to their non-harmful nature. Medicinal plants contain different bioactive compounds, which possess an important role in the prevention of different diseases such as cancer. Plumbagin is a bioactive compound, which is mainly present in Plumbaginaceae family and has been explored for its anticancer activity. Plumbagin basically inactivates the Akt/NF-kB, MMP-9 and VEGF pathways that are essential for cancer cell development. Therefore, it is important to review the role of plumbagin in different cancer cells in order to find an alternative drug to overcome this disease. The present review provides a summary of anticancer activity of plumbagin in various cancers and its mode of action.
癌症是一种致命的疾病，在发达国家和发展中国家都有显著增加。利用放射疗法或化学疗法治疗癌症会引发一些问题，包括呕吐、疾病、不良反应等。在这种情况下，寻找一种有效的治疗癌症的替代药物来源至关重要。由于其无毒的特性，从植物来源获得的产品被用于治疗各种疾病。药用植物含有不同的生物活性化合物，这些化合物在预防癌症等不同疾病方面发挥着重要作用。白花丹素是一种生物活性化合物，主要存在于白花丹科中，其抗癌活性已被探索。白花丹素主要使 Akt/NF-kB、MMP-9 和 VEGF 途径失活，这些途径对癌细胞的发展至关重要。因此，为了寻找一种克服这种疾病的替代药物，有必要研究白花丹素在不同癌细胞中的作用。本综述总结了白花丹素在各种癌症中的抗癌活性及其作用机制。
