Lin Lie-Chwen, Yang Ling-Ling, Chou Cheng-Jen
National Research Institute of Chinese Medicine, Pettou, Taipei 112, Taiwan, ROC.
Phytochemistry. 2003 Feb;62(4):619-22. doi: 10.1016/s0031-9422(02)00519-8.
Two plumbagic acid glucosides, 3'-O-beta-glucopyranosyl plumbagic acid and 3'-O-beta-glucopyranosyl plumbagic acid methylester along with five naphthoquinones (plumbagin, chitranone, maritinone, elliptinone and isoshinanolone), and five coumarins (seselin, 5-methoxyseselin, suberosin, xanthyletin and xanthoxyletin) were isolated from the roots of Plumbago zeylanica. All coumarins were not previously found in this plant. Cytotoxicity of these compounds to various tumor cells lines was evaluated, and plumbagin significantly suppressed growth of Raji, Calu-1, HeLa, and Wish tumor cell lines.
从白花丹的根部分离出两种白花丹酸葡萄糖苷，即3'-O-β-D-吡喃葡萄糖基白花丹酸和3'-O-β-D-吡喃葡萄糖基白花丹酸甲酯，以及五种萘醌（白花丹素、奇任酮、马里替酮、椭圆玫瑰树碱和异紫花前胡醇）和五种香豆素（蛇床子素、5-甲氧基蛇床子素、苏贝罗辛、花椒毒素和花椒毒酚）。所有香豆素此前在该植物中均未被发现。评估了这些化合物对各种肿瘤细胞系的细胞毒性，结果表明白花丹素能显著抑制Raji、Calu-1、HeLa和Wish肿瘤细胞系的生长。
