Cancer Research Program, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, 695014, India.
Manipal Academy of Higher Education (MAHE), Manipal, 576104, India.
Curr Med Chem. 2024;31(32):5165-5177. doi: 10.2174/0109298673274796240116105555.
Immunotherapy is a newly emerging and effective approach to treating cancer. However, there are many challenges associated with using checkpoint inhibitors in this treatment strategy. The component of the tumor microenvironment plays a crucial role in antitumor immune response, regulating tumor immune surveillance and immunological evasion. Natural products/phytochemicals can modulate the tumor microenvironment and function as immunomodulatory agents. In clinical settings, there is a strong need to develop synergistic combination regimens using natural products that can effectively enhance the therapeutic benefits of immune checkpoint inhibitors relative to their effectiveness as single therapies. The review discusses immunotherapy, its side effects, and a summary of evidence suggesting the use of natural products to modulate immune checkpoint pathways.
免疫疗法是一种新兴且有效的癌症治疗方法。然而，在这种治疗策略中使用检查点抑制剂存在许多挑战。肿瘤微环境的组成部分在抗肿瘤免疫反应中起着关键作用，调节肿瘤免疫监视和免疫逃逸。天然产物/植物化学物质可以调节肿瘤微环境，并作为免疫调节剂发挥作用。在临床环境中，强烈需要开发使用天然产物的协同组合方案，这些天然产物可以有效地增强免疫检查点抑制剂相对于单药治疗的治疗益处。该综述讨论了免疫疗法、其副作用以及使用天然产物调节免疫检查点途径的证据总结。
