LFE Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences, Polytechnic University of Madrid (UPM), Madrid, Spain.
J Strength Cond Res. 2021 Feb 1;35(2):549-561. doi: 10.1519/JSC.0000000000003878.
Romero-Parra, N, Cupeiro, R, Alfaro-Magallanes, VM, Rael, B, Rubio-Arias, JA, Peinado, AB, and Benito, PJ, IronFEMME Study Group. Exercise-induced muscle damage during the menstrual cycle: A systematic review and meta-analysis. J Strength Cond Res 35(2): 549-561, 2021-A strenuous bout of exercise could trigger damage of muscle tissue, and it is not clear how sex hormone fluctuations occurring during the menstrual cycle (MC) affect this response. The aims of this study were to systematically search and assess studies that have evaluated exercise-induced muscle damage (EIMD) in eumenorrheic women over the MC and to perform a meta-analysis to quantify which MC phases display the muscle damage response. The guidelines of the Preferred Reported Items for Systematic Reviews and Meta-Analysis were followed. A total of 19 articles were analyzed in the quantitative synthesis. Included studies examined EIMD in at least one phase of the following MC phases: early follicular phase (EFP), late follicular phase (LFP), or midluteal phase (MLP). The meta-analysis demonstrated differences between MC phases for delayed onset muscle soreness (DOMS) and strength loss (p < 0.05), whereas no differences were observed between MC phases for creatine kinase. The maximum mean differences between pre-excercise and post-exercise for DOMS were EFP: 6.57 (4.42, 8.71), LFP: 5.37 (2.10, 8.63), and MLP: 3.08 (2.22, 3.95), whereas for strength loss were EFP: -3.46 (-4.95, -1.98), LFP: -1.63 (-2.36, -0.89), and MLP: -0.72 (-1.07, -0.36) (p < 0.001). In conclusion, this meta-analysis suggests that hormone fluctuations throughout the MC affect EIMD in terms of DOMS and strength loss. Lower training loads or longer recovery periods could be considered in the EFP, when sex hormone concentrations are lower and women may be more vulnerable to muscle damage, whereas strength conditioning loads could be enhanced in the MLP.
罗梅罗-帕拉（Romero-Parra）、努涅斯（Cupeiro）、阿尔法罗-马加兰内斯（Alfaro-Magallanes）、拉埃尔（Rael）、鲁比奥-阿里亚斯（Rubio-Arias）、佩尼亚多（Peinado）和贝尼托（Benito），IronFEMME 研究小组。月经周期中运动引起的肌肉损伤：系统评价和荟萃分析。J 力量与调节研究 35（2）：549-561，2021-剧烈运动可能会引发肌肉组织损伤，目前尚不清楚月经周期（MC）中发生的性激素波动如何影响这种反应。本研究的目的是系统地搜索和评估评估月经周期中运动引起的肌肉损伤（EIMD）的研究，并进行荟萃分析以量化哪些 MC 阶段显示出肌肉损伤反应。遵循了系统评价和荟萃分析的首选报告项目指南。在定量综合分析中分析了 19 篇文章。纳入的研究在以下 MC 阶段的至少一个阶段检查了 EIMD：早期卵泡期（EFP）、晚期卵泡期（LFP）或中期黄体期（MLP）。荟萃分析表明 MC 阶段之间的延迟性肌肉酸痛（DOMS）和力量下降存在差异（p < 0.05），而 MC 阶段之间肌酸激酶没有差异。DOMS 的最大平均差异是 EFP：6.57（4.42，8.71），LFP：5.37（2.10，8.63），MLP：3.08（2.22，3.95），而力量下降是 EFP：-3.46（-4.95，-1.98），LFP：-1.63（-2.36，-0.89），MLP：-0.72（-1.07，-0.36）（p < 0.001）。总之，这项荟萃分析表明，MC 期间的激素波动会影响 DOMS 和力量下降等 EIMD。在 EFP 中，当性激素浓度较低且女性更容易受到肌肉损伤时，可能需要考虑较低的训练负荷或更长的恢复时间，而在 MLP 中可以增强力量调节负荷。
