University of Palermo, Viale delle Scienze, 90127, Palermo, Italy.
Scuola "Borgese XXVII Maggio", Piazza Contardo Ferrini, 13, 90146, Palermo, Italy.
Arch Virol. 2021 Jan;166(1):271-274. doi: 10.1007/s00705-020-04856-4. Epub 2020 Nov 17.
Viral RNAs can perturb the miRNA regulatory network, competing with host RNAs as part of their infective process. An in silico competing endogenous RNA (ceRNA) analysis has been carried on SARS-CoV-2. The results suggest that, in humans, the decrease of microRNA activity caused by viral RNAs can lead to a perturbation of vesicle trafficking and the inflammatory response, in particular by enhancing KLF10 activity. The results suggest also that, during the study of the mechanics of viral infections, it could be of general interest to investigate the competition of viral RNA with cellular transcripts for shared microRNAs.
病毒 RNA 可以扰乱 miRNA 调控网络，作为其感染过程的一部分，与宿主 RNA 竞争。我们对 SARS-CoV-2 进行了计算机模拟的竞争性内源 RNA (ceRNA) 分析。结果表明，在人类中，病毒 RNA 引起的 miRNA 活性降低可能导致囊泡运输和炎症反应的紊乱，特别是通过增强 KLF10 活性。研究结果还表明，在研究病毒感染机制时，研究病毒 RNA 与细胞转录本对共享 miRNA 的竞争可能具有普遍意义。
